(Kondo Tatsuya) - Kumamoto University Faculty of Life Sciences Departments of Metabolic Medicine
(Motoshima Hiroyuki) - Kumamoto University Faculty of Life Sciences Departments of Metabolic Medicine
(Igata Motoyuki) - Kumamoto University Faculty of Life Sciences Departments of Metabolic Medicine
(Kawashima Junji) - Kumamoto University Faculty of Life Sciences Departments of Metabolic Medicine
(Matsumura Takeshi) - Kumamoto University Faculty of Life Sciences Departments of Metabolic Medicine
(Kai Hirofumi) - Kumamoto University Faculty of Life Sciences Departments of Molecular Medicine
(Araki Eiichi) - Kumamoto University Faculty of Life Sciences Departments of Metabolic Medicine
Abstract
The expansion of life-style related diseases, such as metabolic syndrome (MS) and type 2 diabetes mellitus (T2DM), appears to be unstoppable. It is also difficult to cease their complications in spite of many antidiabetic medications or intervention of public administration. We and our collaborators found that physical medicine using simultaneous stimulation of heat with mild electric current activates heat shock response, thereby reducing visceral adiposity, insulin resistance, chronic inflammation and improving glucose homeostasis in mice models of T2DM, as well as in humans with MS or T2DM. This combination therapy exerts novel action on insulin signaling, ¥â-cell protection and body compositions, and may provide a new therapeutic alternative in diabetic treatment strategy.
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Chronic inflammation, Cytoprotection, Diabetes mellitus, Heat-shock response
KMID :
1200020140380020100
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