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A Case of Non-small Cell Lung Cancer Patient Whose Dermatologic Adverse Reactions Associated with the Epidermal Growth Factor Receptor-inhibitors were Relieved with the Treatment of a Herbal medicine, Samultang-gagambang
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¹ÚÇüÁØ(Park Hyeong-Jun) - °æÈñ´ëÇб³ ÇÑÀÇ°ú´ëÇÐ ÀÓ»óÁ¾¾çÇаú
äÁø(Chae-Jean) - °æÈñ´ëÇб³ ÇÑÀÇ°ú´ëÇÐ ÀÓ»óÁ¾¾çÇаú
ÀÌÁø¼ö(Lee Jin-Soo) - °æÈñ´ëÇб³ ÇÑÀÇ°ú´ëÇÐ ÀÓ»óÁ¾¾çÇаú
Á¤Çö½Ä(Jung Hyun-Sik) - °µ¿°æÈñ´ëÇб³º´¿ø Çѹ泻°ú
ÀÌ»óÇå(Lee Sang-Hun) - °µ¿°æÈñ´ëÇб³º´¿ø Çѹ泻°ú
ÃÖ¿øö(Choi Won-Chul) - °æÈñ´ëÇб³ ÇÑÀÇ°ú´ëÇÐ ÀÓ»óÁ¾¾çÇаú
±è°æ¼®(Kim Kyung-Suk) - °µ¿°æÈñ´ëÇб³º´¿ø Çѹ泻°ú
Abstract
Objectives:Epidermal growth factor receptor-inhibitors have demonstrated improved overall survival in patients with non-small cell lung cancer, but their use is associated with dermatologic adverse reactions that often require symptomatic treatment.
Methods:A 44-year-old woman, who started the chemotherapy of Iressa(R) on August 2010, developed cutaneous symptoms such as papulopustular rash, dry skin, and pruritus on her face and scalp after taking Iressa(R) for four weeks. The patient visited our clinic with such symptoms on March 2011 and underwent herebal remedy targeted to alleviate the skin reactions. The severity of dermatologic symptoms was evaluated with the numeric rating scale and the Common Terminology Criteria for Adverse Events version 4.0.
Results: Noticeable changes on the skin lesion were observed after the two months of treatment, without any dose modification of the Iressa(R). The cutaneous symptoms as papulopustular rash, dry skin and pruritus were improved and there was no adverse event induced by the treatment with herbal medicine.
Conclusions :This case report suggests that the treatment with a herbal medicine, Samultang-gagambang be considered as a useful treatment to relieve EGFR-inhibitor induced dermatologic adverse reactions.
Å°¿öµå
dermatologic side effects, EGFR inhibitor, Iressa(R), herbal medicine
KMID :
1191520110160010055
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Treatment with a herbal medicine (Samultang-gagambang) be considered as a useful treatment to relieve EGFR-inhibitor induced dermatologic adverse reactions.