Microsatellite Instability of Gastric and Colorectal Cancers as a Predictor of Synchronous Gastric or Colorectal Neoplasms
Gut and Liver 2016³â 10±Ç 2È£ p.220 ~ p.227
(Kim Young-Beak) - Konkuk University School of Medicine Department of Internal Medicine
À̼±¿µ(Lee Sun-Young) - Konkuk University School of Medicine Department of Internal Medicine
±èÁ¤È¯(Kim Jeong-Hwan) - Konkuk University School of Medicine Department of Internal Medicine
¼ºÀΰæ(Sung In-Kyung) - Konkuk University School of Medicine Department of Internal Medicine
¹ÚÇü¼®(Park Hyung-Seok) - Konkuk University School of Medicine Department of Internal Medicine
½ÉÂù¼·(Shim Chan-Sup) - Konkuk University School of Medicine Department of Internal Medicine
ÇÑÇý½Â(Han Hye-Seung) - Konkuk University School of Medicine Department of Pathology
Abstract
Background/Aims:Microsatellite instability (MSI) plays a crucial role in gastrointestinal carcinogenesis. The aim of this study was to clarify whether MSI is a useful marker for predicting synchronous gastric and colorectal neoplasms.
Methods:Consecutive patients who underwent both esophagogastroduodenoscopy and colonoscopy before the resection of gastric or colorectal cancers were included. MSI was analyzed using two mononucleotide and three dinucleotide markers.
Results:In total, 434 gastric cancers (372 microsatellite stability [MSS], 21 low incidence of MSI [MSI-L], and 41 high incidence of MSI [MSI-H]) and 162 colorectal cancers (138 MSS, 9 MSI-L, and 15 MSI-H) were included. Patients with MSI gastric cancer had a higher prevalence of synchronous colorectal cancer, colorectal adenoma, and gastric adenoma than those with MSS gastric cancers (4.8% vs 0.5%, p=0.023; 11.3% vs 3.2%, p=0.011; 3.2% vs 1.2%, p=0.00, respectively). The prevalence of synchronous colorectal adenomas was highest in MSI-L gastric cancers (19.0%), compared with MSI-H (7.3%) or MSS (3.2%) gastric cancers (p=0.002). In addition, there were no significant differences in the prevalence rates of synchronous colorectal adenoma among the MSI-H (13.3%), MSI-L (11.1%), and MSS (12.3%) colorectal cancers (p=0.987).
Conclusions:The presence of MSI in gastric cancer may be a predictor of synchronous gastric and colorectal neoplasms, whereas MSI in colorectal cancer is not a predictor of synchronous colorectal adenoma.
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Microsatellite instability, Stomach neoplasms, Colorectal neoplasms, Adenoma
KMID :
1188320160100020220
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MSI in colorectal cancer is not a predictor of synchronous colorectal adenoma.