Esophageal Squamous Cell Carcinoma Patients Have an Increased Risk of Coexisting Colorectal Neoplasms
Gut and Liver 2016³â 10±Ç 1È£ p.76 ~ p.82
¹é¸í±â(Baeg Myong-Ki) - Catholic University Seoul St. Mary¡¯s Hospital Department of Internal Medicine
ÃÖ¸í±Ô(Choi Myung-Gyu) - Catholic University Seoul St. Mary¡¯s Hospital Department of Internal Medicine
Á¤À±´ö(Jung Yun-Duk) - Catholic University Seoul St. Mary¡¯s Hospital Department of Internal Medicine
°í¼±Çý(Ko Sun-Hye) - Catholic University Seoul St. Mary¡¯s Hospital Department of Internal Medicine
ÀÓöÇö(Lim Chul-Hyun) - Catholic University Seoul St. Mary¡¯s Hospital Department of Internal Medicine
±èÇüÈÆ(Kim Hyung-Hun) - Catholic University Seoul St. Mary¡¯s Hospital Department of Internal Medicine
±èÁø¼ö(Kim Jin-Su) - Catholic University Seoul St. Mary¡¯s Hospital Department of Internal Medicine
Á¶À¯°æ(Cho Yu-Kyung) - Catholic University Seoul St. Mary¡¯s Hospital Department of Internal Medicine
¹ÚÀç¸í(Park Jae-Myung) - Catholic University Seoul St. Mary¡¯s Hospital Department of Internal Medicine
ÀÌÀμ®(Lee In-Seok) - Catholic University Seoul St. Mary¡¯s Hospital Department of Internal Medicine
±è»ó¿ì(Kim Sang-Woo) - Catholic University Seoul St. Mary¡¯s Hospital Department of Internal Medicine
Abstract
Background/Aims:Esophageal squamous cell carcinoma (ESCC) and colorectal neoplasms (CRNs) share risk factors. We aimed to investigate whether the CRN risk is increased in ESCC patients.
Methods:ESCC patients who underwent a colonoscopy within 1 year of diagnosis were retrospectively analyzed. Patients were matched 1:3 by age, gender, and body mass index to asymptomatic controls. CRN was defined as the histological confirmation of adenoma or adenocarcinoma. Advanced CRN was defined as any of the following: ¡Ã3 adenomas, high-grade dysplasia, villous features, tumor ¡Ã1 cm, or adenocarcinoma. The risk factors for both CRN and advanced CRN were evaluated by univariate and multivariate analyses.
Results:Sixty ESCC patients were compared with 180 controls. The ESCC group had significantly higher numbers of CRNs (odds ratio [OR], 2.311; 95% confidence interval [CI], 1.265 to 4.220; p=0.006) and advanced CRNs (OR, 2.317; 95% CI, 1.185 to 4.530; p=0.013). Significant risk factors for both CRN and advanced CRN by multivariate analysis included ESCC (OR, 2.157, 95% CI, 1.106 to 4.070, p=0.024; and OR, 2.157, 95% CI, 1.045 to 4.454, p=0.038, respectively) and older age (OR, 1.068, 95% CI, 1.032 to 1.106, p<0.001; and OR, 1.065, 95% CI, 1.024 to 1.109, p=0.002, respectively).
Conclusions:The rates of CRN and advanced CRN are significantly increased in ESCC. Colonos-copy should be considered at ESCC diagnosis.
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Colorectal neoplasms, Esophageal neoplasms, Esophageal squamous cell carcinoma, Colonoscopy, Colorectal adenoma and carcinoma
KMID :
1188320160100010076
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The risk of CRN and advanced CRN is increased significantly in ESCC patients.