Long-Term Outcomes of NSAID-Induced Small Intestinal Injury Assessed by Capsule Endoscopy in Korea: A Nationwide Multicenter Retrospective Study
Gut and Liver 2015³â 9±Ç 6È£ p.727 ~ p.733
½É±â³²(Shim Ki-Nam) - Ewha Womans University School of Medicine Department of Internal Medicine
¼ÛÀº¹Ì(Song Eun-Mi) - Ewha Womans University School of Medicine Department of Internal Medicine
ÁøÀ±ÅÂ(Jeen Yoon-Tae) - Korea University College of Medicine Department of Internal Medicine
±èÁø¿À(Kim Jin-Oh) - Soonchunhyang University College of Medicine Department of Internal Medicine
Àü¼º¶õ(Jeon Seong-Ran) - Soonchunhyang University College of Medicine Department of Internal Medicine
À嵿°æ(Chang Dong-Kyung) - Sungkyunkwan University School of Medicine Department of Internal Medicine
¼ÛÇöÁÖ(Song Hyun-Joo) - Jeju National University School of Medicine Department of Internal Medicine
ÀÓÀ±Á¤(Lim Yun-Jeong) - Dongguk University College of Medicine Department of Internal Medicine
±èÁø¼ö(Kim Jin-Soo) - Catholic University College of Medicine Department of Internal Medicine
¿¹º´´ö(Ye Byong-Duk) - University of Ulsan College of Medicine Department of Gastroenterology
¹ÚöÈñ(Park Cheol-Hee) - Hallym University College of Medicine Department of Internal Medicine
Àü¼º¿ì(Jeon Seong-Woo) - Kyungpook National University School of Medicine Department of Internal Medicine
õÀçÈñ(Cheon Jae-Hee) - Yonsei University College of Medicine Department of Internal Medicine
À̱¤Àç(Lee Kwang-Jae) - Ajou University School of Medicine Department of Gastroenterology
±èÁöÇö(Kim Ji-Hyun) - Inje University College of Medicine Department of Gastroenterology
À庴ÀÍ(Jang Byung-Ik) - Yeungnam University College of Medicine Department of Internal Medicine
¹®Á¤¼·(Moon Jeong-Seop) - Inje University College of Medicine Department of Internal Medicine
(Chun Hoon-Jae) - Korea University College of Medicine Department of Internal Medicine
ÃÖ¸í±Ô(Choi Myung-Gyu) - Catholic University College of Medicine Department of Internal Medicine
Abstract
Background/Aims:We evaluated the long-term outcome and clinical course of patients of nonsteroidal anti-inflammatory drug (NSAID)-induced small intestinal injury by performing capsule endoscopy (CE).
Methods:A multicenter retrospective study was conducted using data collected from the CE nationwide database registry, which has been established since 2002.
Results:A total of 140 patients (87 males; mean age, 60.6¡¾14.8 years) from the CE nationwide database registry (n=2,885) were diagnosed with NSAID-induced small intestinal injury and enrolled in our study. Forty-nine patients (35.0%) presented with a history of aspirin use and an additional 49 (35.0%) were taking NSAIDs without aspirin. The most prominent findings after performing CE were multiple ulcerations (n=82, 58.6%) and erosions or aphthae (n=32, 22.9%). During the follow-up period (mean, 15.9¡¾19.0 months; range, 0 to 106 months), NSAID-induced small intestinal injury only recurred in six patients (4.3%). Older age and hypertension were positive predictive factors for recurrence.
Conclusions:These results suggest that the recurrence of NSAID-induced small bowel injury was not frequent in the presence of conservative treatment. Therefore, the initial diagnosis using CE and the medication history are important.
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Anti-inflammatory agents, non-steroidal, Capsule endoscopy, Outcome
KMID :
1188320150090060727
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The most prominent findings after performing CE were multiple ulcerations (n=82, 58.6%) and erosions or aphthae (n=32, 22.9%); The initial diagnosis using CE and the medication history are important