Long-Term Outcomes of NSAID-Induced Small Intestinal Injury Assessed by Capsule Endoscopy in Korea: A Nationwide Multicenter Retrospective Study

Gut and Liver 2015년 9권 6호 p.727 ~ p.733

심기남(Shim Ki-Nam) - Ewha Womans University School of Medicine Department of Internal Medicine
송은미(Song Eun-Mi) - Ewha Womans University School of Medicine Department of Internal Medicine
진윤태(Jeen Yoon-Tae) - Korea University College of Medicine Department of Internal Medicine
김진오(Kim Jin-Oh) - Soonchunhyang University College of Medicine Department of Internal Medicine
전성란(Jeon Seong-Ran) - Soonchunhyang University College of Medicine Department of Internal Medicine
장동경(Chang Dong-Kyung) - Sungkyunkwan University School of Medicine Department of Internal Medicine
송현주(Song Hyun-Joo) - Jeju National University School of Medicine Department of Internal Medicine
임윤정(Lim Yun-Jeong) - Dongguk University College of Medicine Department of Internal Medicine
김진수(Kim Jin-Soo) - Catholic University College of Medicine Department of Internal Medicine
예병덕(Ye Byong-Duk) - University of Ulsan College of Medicine Department of Gastroenterology
박철희(Park Cheol-Hee) - Hallym University College of Medicine Department of Internal Medicine
전성우(Jeon Seong-Woo) - Kyungpook National University School of Medicine Department of Internal Medicine
천재희(Cheon Jae-Hee) - Yonsei University College of Medicine Department of Internal Medicine
이광재(Lee Kwang-Jae) - Ajou University School of Medicine Department of Gastroenterology
김지현(Kim Ji-Hyun) - Inje University College of Medicine Department of Gastroenterology
장병익(Jang Byung-Ik) - Yeungnam University College of Medicine Department of Internal Medicine
문정섭(Moon Jeong-Seop) - Inje University College of Medicine Department of Internal Medicine
(Chun Hoon-Jae) - Korea University College of Medicine Department of Internal Medicine
최명규(Choi Myung-Gyu) - Catholic University College of Medicine Department of Internal Medicine

Abstract

Background/Aims:We evaluated the long-term outcome and clinical course of patients of nonsteroidal anti-inflammatory drug (NSAID)-induced small intestinal injury by performing capsule endoscopy (CE).

Methods:A multicenter retrospective study was conducted using data collected from the CE nationwide database registry, which has been established since 2002.

Results:A total of 140 patients (87 males; mean age, 60.6±14.8 years) from the CE nationwide database registry (n=2,885) were diagnosed with NSAID-induced small intestinal injury and enrolled in our study. Forty-nine patients (35.0%) presented with a history of aspirin use and an additional 49 (35.0%) were taking NSAIDs without aspirin. The most prominent findings after performing CE were multiple ulcerations (n=82, 58.6%) and erosions or aphthae (n=32, 22.9%). During the follow-up period (mean, 15.9±19.0 months; range, 0 to 106 months), NSAID-induced small intestinal injury only recurred in six patients (4.3%). Older age and hypertension were positive predictive factors for recurrence.

Conclusions:These results suggest that the recurrence of NSAID-induced small bowel injury was not frequent in the presence of conservative treatment. Therefore, the initial diagnosis using CE and the medication history are important.

키워드

Anti-inflammatory agents, non-steroidal, Capsule endoscopy, Outcome
원문 및 링크아웃 정보
등재저널 정보
SCI(E) MEDLINE 학술진흥재단(KCI) KoreaMed 
주제코드
주제명(Target field)
연구대상(Population)
연구참여(Sample size)
대상성별(Gender)
질병특성(Condition Category)
연구환경(Setting)
연구설계(Study Design)
연구기간(Period)
중재방법(Intervention Type)
중재명칭(Intervention Name)
키워드(Keyword)
유효성결과(Recomendation)
The most prominent findings after performing CE were multiple ulcerations (n=82, 58.6%) and erosions or aphthae (n=32, 22.9%); The initial diagnosis using CE and the medication history are important
연구비지원(Fund Source)
근거수준평가(Evidence Hierarchy)
출판년도(Year)
참여저자수(Authors)
대표저자
KCD코드
ICD 03
건강보험코드