An Inverse Relationship between the Expression of the Gastric Tumor Suppressor RUNX3 and Infection with Helicobacter pylori in Gastric Epithelial Dysplasia
Gut and Liver 2013³â 7±Ç 6È£ p.688 ~ p.695
Á¤¿ìö(Chung Woo-Chul) - Catholic University College of Medicine St. Vincent¡¯s Hospital Department of Internal Medicine
Á¤¼ºÈÆ(Jung Sung-Hoon) - Catholic University College of Medicine Department of Internal Medicine
ÁÖ°Ü·¹(Joo Kyu-Re) - Catholic University College of Medicine St. Vincent¡¯s Hospital Department of Internal Medicine
±è¹ÎÁö(Kim Min-Ji) - Catholic University College of Medicine St. Vincent¡¯s Hospital Department of Internal Medicine
À±°ÇÁß(Youn Gun-Jung) - Catholic University College of Medicine Department of Internal Medicine
±è¿¹´Ï(Kim Yae-Ni) - Catholic University College of Medicine Department of Internal Medicine
ÀÌÁؼ·(Lee Joune-Seup) - Catholic University College of Medicine Department of Internal Medicine
ÀÌÇý¿ø(Lee Hye-Won) - Catholic University College of Medicine Department of Internal Medicine
Á¤ÁöÇÑ(Jung Ji-Han) - Catholic University College of Medicine Department of Pathology
ÀÌÀ±°æ(Lee Yun-Kyung) - Sungkyunkwan University School of Medicine Samsung Medical Center Department of Pathology
Abstract
Background/Aims:This study was performed to determine the association between RUNX3 expression and Helicobacter pylori infection in premalignant gastric lesions.
Methods:We examined 107 patients with gastric epithelial dysplasia who had undergone endoscopic mucosal resection or submucosal dissection. All tissue samples were evaluated by RUNX3 staining and subclassified by immunophenotype. H. pylori infection in dysplastic lesions and the normal surrounding tissue was examined by silver staining, and cagA status was assessed by polymerase chain reaction.
Results:The loss of RUNX3 expression was observed in 62 cases (57.9%), and an association with H. pylori infection was found in 54 cases (50.5%). The infection rate with the cagA-positive H. pylori strain was 63.0%. In RUNX3-negative lesions, the rate of H. pylori infection (p=0.03) and the frequency of category 4 lesions (according to the revised Vienna classification) were high (p=0.02). In addition, the gastric mucin phenotype was predominant. In RUNX3-negative category 4 lesions, the rate of cagA-positive H. pylori infection rate was high but not significantly increased (p=0.08).
Conclusions:Infection with H. pylori is associated with inactivation of RUNX3 in early gastric carcinogenesis. This mechanism was prominent in gastric cancer with a gastric mucin phenotype.
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Helicobacter pylori, CagA protein, Core binding factor alpha 3 subunit
KMID :
1188320130070060688
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Infection with H. pylori is associated with inactivation of RUNX3 in early gastric carcinogenesis.