An Inverse Relationship between the Expression of the Gastric Tumor Suppressor RUNX3 and Infection with Helicobacter pylori in Gastric Epithelial Dysplasia
Gut and Liver 2013년 7권 6호 p.688 ~ p.695
정우철(Chung Woo-Chul) - Catholic University College of Medicine St. Vincent’s Hospital Department of Internal Medicine
정성훈(Jung Sung-Hoon) - Catholic University College of Medicine Department of Internal Medicine
주겨레(Joo Kyu-Re) - Catholic University College of Medicine St. Vincent’s Hospital Department of Internal Medicine
김민지(Kim Min-Ji) - Catholic University College of Medicine St. Vincent’s Hospital Department of Internal Medicine
윤건중(Youn Gun-Jung) - Catholic University College of Medicine Department of Internal Medicine
김예니(Kim Yae-Ni) - Catholic University College of Medicine Department of Internal Medicine
이준섭(Lee Joune-Seup) - Catholic University College of Medicine Department of Internal Medicine
이혜원(Lee Hye-Won) - Catholic University College of Medicine Department of Internal Medicine
정지한(Jung Ji-Han) - Catholic University College of Medicine Department of Pathology
이윤경(Lee Yun-Kyung) - Sungkyunkwan University School of Medicine Samsung Medical Center Department of Pathology
Abstract
Background/Aims:This study was performed to determine the association between RUNX3 expression and Helicobacter pylori infection in premalignant gastric lesions.
Methods:We examined 107 patients with gastric epithelial dysplasia who had undergone endoscopic mucosal resection or submucosal dissection. All tissue samples were evaluated by RUNX3 staining and subclassified by immunophenotype. H. pylori infection in dysplastic lesions and the normal surrounding tissue was examined by silver staining, and cagA status was assessed by polymerase chain reaction.
Results:The loss of RUNX3 expression was observed in 62 cases (57.9%), and an association with H. pylori infection was found in 54 cases (50.5%). The infection rate with the cagA-positive H. pylori strain was 63.0%. In RUNX3-negative lesions, the rate of H. pylori infection (p=0.03) and the frequency of category 4 lesions (according to the revised Vienna classification) were high (p=0.02). In addition, the gastric mucin phenotype was predominant. In RUNX3-negative category 4 lesions, the rate of cagA-positive H. pylori infection rate was high but not significantly increased (p=0.08).
Conclusions:Infection with H. pylori is associated with inactivation of RUNX3 in early gastric carcinogenesis. This mechanism was prominent in gastric cancer with a gastric mucin phenotype.
키워드
Helicobacter pylori, CagA protein, Core binding factor alpha 3 subunit
KMID :
1188320130070060688
원문 및 링크아웃 정보
등재저널 정보
유효성결과(Recomendation)
Infection with H. pylori is associated with inactivation of RUNX3 in early gastric carcinogenesis.