Bowel Preparation for Capsule Endoscopy: A Prospective Randomized Multicenter Study

Gut and Liver 2009년 3권 3호 p.180 ~ p.185

위준환(Wi Jun-Hwan) - 순천향대학교 의과대학 내과학교실
문정섭(Moon Jeong-Seop) - 인제대학교 의과대학 서울백병원 내과학교실
최명규(Choi Myung-Gyu) - 가톨릭대학교 의과대학 내과학교실
김진오(Kim Jin-Oh) - 순천향대학교병원 소화기연구소
도재혁(Do Jae-Hyuk) - 중앙대학교 의과대학 내과학교실
류지곤(Ryu Ji-Kon) - 서울대학교 의과대학 내과학교실, 간연구소
심기남(Shim Ki-Nam) - 이화여자대학교 의과대학 내과학교실
이광재(Lee Kwang-Jae) - 아주대학교 의과대학 소화기내과학교실
장병익(Jang Byung-Ik) - 영남대학교 의과대학 내과학교실
전훈재(Chun Hoon-Jai) - 고려대학교 의과대학 내과학교실, 소화기연구소


Background/Aims: The ability to visualize the small bowel mucosa by capsule endoscopy is limited. Moreover, studies involving small-bowel preparation with purgative drugs have failed to establish which preparations produce better images and higher diagnostic yields. The aim of this study was to evaluate the efficacies and diagnostic yields of different bowel preparations.

Methods: A cohort of 134 patients with suspected small bowel disease was randomly assigned to 3 groups. Patients in group A (n=44) fasted for 12 h before being administered an M2A capsule (Given Imaging, Yoqneam, Israel). Patients in group B (n=45) were asked to drink two doses of 45 mL of sodium phosphate (NaP) with water during the afternoon and evening on the day before the procedure and to drink at least 2 L of water thereafter. Patients in group C (n=45) drank 2 L of a polyethylene glycol (PEG) lavage solution the evening before the procedure.

Results: Overall cleansing of the small bowel was adequate in 43% of patients in group A, 77% of those in group B, and 56% of those in group C (group A vs group B, p=0.001). Diagnoses for obscure gastrointestinal bleeding were established in 9 patients (39%) in group A, 16 patients (69%) in group B, and 14 patients (50%) in group C. No significant difference in diagnostic yield was observed between groups.

Conclusions: Bowel preparation with NaP for capsule endoscopy improved small-bowel mucosal visualization when compared to 12-h overnight fasting.


Capsule endoscopy, Sodium phosphate
원문 및 링크아웃 정보
등재저널 정보
SCI(E) MEDLINE 학술진흥재단(KCI) KoreaMed 
주제명(Target field)
연구참여(Sample size)
질병특성(Condition Category)
연구설계(Study Design)
중재방법(Intervention Type)
중재명칭(Intervention Name)
Bowel preparation with NaP improves the quality of capsule endoscopy images.
연구비지원(Fund Source)
근거수준평가(Evidence Hierarchy)
ICD 03