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Study of Dynamic Variation Aspect in Lung Volume due to Respiration in Stereotactic Body Radiotherapy Using Abdominal Compressor

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¹Ú±¤¼ø(Park Kwang-Soon) - ¿¬¼¼ÀÇ·á¿ø ¾Ï¼¾ÅÍ ¹æ»ç¼±Á¾¾çÇаú
±èÁÖÈ£(Kim Joo-Ho) - ¿¬¼¼ÀÇ·á¿ø ¾Ï¼¾ÅÍ ¹æ»ç¼±Á¾¾çÇаú
¹ÚÈ¿±¹(Park Hyo-Kuk) - ¿¬¼¼ÀÇ·á¿ø ¾Ï¼¾ÅÍ ¹æ»ç¼±Á¾¾çÇаú
¹éÁ¾°É(Baek Jong-Geal) - ¿¬¼¼ÀÇ·á¿ø ¾Ï¼¾ÅÍ ¹æ»ç¼±Á¾¾çÇаú
ÀÌ»ó±Ô(Lee Sang-Kyu) - ¿¬¼¼ÀÇ·á¿ø ¾Ï¼¾ÅÍ ¹æ»ç¼±Á¾¾çÇаú
À±Á¾¿ø(Yoon Jong-Won) - ¿¬¼¼ÀÇ·á¿ø ¾Ï¼¾ÅÍ ¹æ»ç¼±Á¾¾çÇаú
Á¶Á¤Èñ(Cho Jung-Heui) - ¿¬¼¼ÀÇ·á¿ø ¾Ï¼¾ÅÍ ¹æ»ç¼±Á¾¾çÇаú

Abstract

¸ñÀû: º¹ºÎ¾Ð¹ÚÀåÄ¡¸¦ Àû¿ëÇÑ Á¤À§Àû¹æ»ç¼±Ä¡·á ½Ã ȯÀÚ È£Èí¿¡ ±âÀÎÇÏ´Â ³»ºÎÁ¾¾ç¿ëÀûÀÇ µ¿Àûº¯ÀÌ ¾ç»óÀ» ¿¬±¸ÇÏ°íÀÚ ÇÏ¿´
´Ù.

´ë»ó ¹× ¹æ¹ý: 2012³â 4¿ùºÎÅÍ 2013³â 4¿ù±îÁö º¹ºÎ¾Ð¹ÚÀåÄ¡¸¦ ÀÌ¿ëÇÏ¿© Á¤À§Àû¹æ»ç¼±Ä¡·á¸¦ ¹ÞÀº Æó¾Ï ȯÀÚ 20¸í(»ó¿± 7¸í,
Áß¿± 4¸í, ÇÏ¿± 9¸í), ÃÑ 67°ÇÀ» ´ë»óÀ¸·Î ÇÏ¿´´Ù. Ä¡·á ÀÚ¼¼ÀÇ º¯µ¿°ú È£Èí¿¡ ÀÇÇØ ¿òÁ÷ÀÌ´Â Á¾¾ç À§Ä¡ º¯µ¿À» ¾Ë¾Æº¸±â À§ÇØ
4Â÷¿ø cone- beam CT (4D-CBCT)¸¦ »ç¿ëÇÏ¿© ÁÂÇ¥ À̵¿ °ªÀ» ¾ò¾ú´Ù. °¢ ºÎÀ§º°·Î LR (Á¿ì), SI (»óÇÏ), AP (ÀüÈÄ) ¹æÇâÀÇ
º¤ÅÍÀÇ 95% ½Å·Ú±¸°£(95% Confidence interval, 95% CI), ÃÖ´ë°ª, ±×¸®°í ÃÖ¼Ò°ªÀ» ÅëÇÏ¿© ºñ±³ÇÏ¿´À¸¸ç ÀÚ¼¼º¯µ¿ º¸Á¤ °ª°ú
È£Èíº¯µ¿ º¸Á¤ °ª °£ÀÇ ÇǾ °ö »ó°ü°è¼ö¸¦ ÅëÇÏ¿© ÀÏÄ¡µµ¸¦ ºÐ¼®ÇÏ¿´´Ù.

°á°ú: È£Èí¿¡ ÀÇÇÑ Á¾¾ç¿ëÀûÀÇ °¢ ºÎÀ§º°·Î º¯µ¿Àº Æó »ó¿±¿¡¼­ 1.8¡­2.9 mm, Áß¿±°ú ÇÏ¿±¿¡¼­ 2.3¡­5.4 mm, 2.2¡­4.0 mm·Î
ºÐ¼®µÇ¾ú´Ù(95%CI, P£¼0.001). ÀÚ¼¼º¯µ¿ º¸Á¤ °ª°ú È£Èíº¯µ¿ º¸Á¤ °ª °£ÀÇ ÀÏÄ¡µµ(R2)¸¦ »ìÆ캸¸é »ó¿±Àº LR¹æÇâ, SI¹æÇâ, AP
¹æÇâ¿¡¼­ °¢°¢ 0.75, 0.68, 0.63À¸·Î ³ªÅ¸³µ°í, Áß¿±Àº °¢°¢ 0.82, 0.51, 0.92·Î ³ªÅ¸³µÀ¸¸ç, ÇÏ¿±Àº °¢°¢ 0.63, 0.50, 0.34·Î ³ªÅ¸³µ
´Ù.

°á·Ð: Æó¾ÏÀÇ Á¤À§Àû¹æ»ç¼± Ä¡·á ½Ã º¹ºÎ¾Ð¹ÚÀåÄ¡ÀÇ »ç¿ëÀ¸·Î Æó¿¡ À§Ä¡ÇÏ´Â Á¾¾çÀº ȯÀÚ È£Èí¿¡ ÀÇÇØ °¢ ºÎÀ§º°·Î °¢±â ´Ù
¸¥ ¾ç»óÀ» º¸¿´´Ù. µû¶ó¼­ Ä¡·á ÀÚ¼¼¿¡ ´ëÇÑ º¸Á¤»Ó¸¸ ¾Æ´Ï¶ó È£Èí¿¡ ÀÇÇÑ º¯µ¿À» º¸Á¤Çؾ߸¸ ÇÑ´Ù. ¶ÇÇÑ ÀÌ·¯ÇÑ °¢±â ´Ù¸¥
µ¿Àûº¯ÀÌ·Î ÀÎÇÑ ¿ÀÂ÷ÀÇ º¸Á¤ ½Ã 4D-CBCTÀÇ »ç¿ëÀº ¸Å¿ì À¯¿ëÇÑ °ÍÀ¸·Î »ç·áµÈ´Ù.
Purpose: Abdominal compressor is used to control breathing in stereotactic body radiotherapy for lung tumors
frequently. We evaluated the dynamic variation aspect of internal tumor volume by breathing.

Materials and Methods: We reviewed 20 lung cancer patients (7 upper lung patients, 4 middle lung patients, 9
lower lung patients) who received stereotactic body radiotherapy using abdominal compressor between April 2012
to April 2013. Coordinate shift values were obtained by using four-dimensional cone-beam CT (4D-CBCT) to
investigate treatment set-up error and moving tumor position error. To investigate how much difference of each
part, we compared 95% confidence interval, maximum values and minimum values of three-dimensional vector
value and analyzed conformity degree through the Pearson square correlation coefficient.

Results: 95% confidence interval of three-dimensional vector value of each part is 1.8¡­2.9 mm in upper lobe, 2.3
¡­5.4 mm in middle lobe and 2.2¡­4.0 mm in lower lobe. Conformity degree was the result that respectively is LR
direction 0.75, SI direction 0.68 and AP direction 0.63 in upper lobe, LR direction 0.82, SI direction 0.51 and AP
direction 0.92 in middle lobe and LR direction 0.63, SI direction 0.50 and AP direction 0.34 in lower lobe.

Conclusion: We showed difference by each site in lung tumor due to respiration by using abdominal compressor.
Therefore, we must correct treatment set-up error as well as moving tumor position error by breathing. It is also
considered to be useful that it is the use of 4D-CBCT when correcting the error due to various dynamic variation.

Å°¿öµå

Á¤À§Àû¹æ»ç¼±Ä¡·á, 4Â÷¿ø Äܺö CT, º¹ºÎ¾Ð¹ÚÀåÄ¡
stereotactic body radiotherapy (SBRT), 4D-cone beam CT, abdominal compressor
¿ø¹® ¹× ¸µÅ©¾Æ¿ô Á¤º¸
µîÀçÀú³Î Á¤º¸
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ÁÖÁ¦¸í(Target field)
¿¬±¸´ë»ó(Population)
¿¬±¸Âü¿©(Sample size)
´ë»ó¼ºº°(Gender)
Áúº´Æ¯¼º(Condition Category)
¿¬±¸È¯°æ(Setting)
¿¬±¸¼³°è(Study Design)
¿¬±¸±â°£(Period)
ÁßÀç¹æ¹ý(Intervention Type)
ÁßÀç¸íĪ(Intervention Name)
Å°¿öµå(Keyword)
À¯È¿¼º°á°ú(Recomendation)
Conformity degree was the result that respectively is LR direction 0.75, SI direction 0.68 and AP direction 0.63 in upper lobe, LR direction 0.82, SI direction 0.51 and AP direction 0.92 in middle lobe and LR direction 0.63, SI direction 0.50 and AP direction 0.34 in lower lobe.
¿¬±¸ºñÁö¿ø(Fund Source)
±Ù°Å¼öÁØÆò°¡(Evidence Hierarchy)
ÃâÆdz⵵(Year)
Âü¿©ÀúÀÚ¼ö(Authors)
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DOI
KCDÄÚµå
ICD 03
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