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신경병증 통증 쥐 척수강 내로 투여한 Tianeptine의 항이질통 효과
Antiallodynic effects of intrathecal tianeptine in a neuropathic pain rat

Anesthesia and Pain Medicine 2014년 9권 2호 p.93 ~ p.97

림해(Lin Hai) - 전남대학교 의과대학 마취통증의학교실
이형곤(Lee Hyung-Gon) - 전남대학교 의과대학 마취통증의학교실
유명하(Yoon Myung-Ha) - 전남대학교 의과대학 마취통증의학교실

Abstract

Background:Tianeptine is an antidepressant drug which is used for treating depression. Interestingly, the tianeptine has shown antinociceptive effects within a variety of nociceptions. The aim of this study is to investigate the antiallodynic effects of tianeptine in neuropathic pain rats and also determine the involvements of serotonergic, alpha-2 adrenergic and adenosine receptors at the spinal level.

Methods:Neuropathic pain was induced by ligation of left lumbar at 5th and 6th spinal nerves in male Sprague-Dawley rats. PE-10 catheters were placed into the thoracolumbar subarachnoid space for drug injections. Mechanical allodynia was evaluated by mea-suring the withdrawal threshold to von Frey filament when applying on the plantar surface of rats. The effects of intrathecal tianeptine were observed at 15, 30, 60, 90, 120, 150, 180 minutes after delivery. Antagonists for serotonergic (dihydroergocristine), alpha-2 adrenergic (yohimbine) and adenosine (CGS 15943) receptors were intrathecally administered 10 minutes prior to tianeptine in order to evaluate the involvement of both receptors.

Results:Intrathecal tianeptine increased dose-dependently at the withdrawal threshold in the ligated paw. Pretreatment with intrat-hecal dihydroergocristine, yohimbine and CGS 15943 antagonized the antiallodynic effects of tianeptine.

Conclusions: These results suggested that intrathecal tianeptine attenuates the spinal nerve ligation induced tactile allodynia. Serotonergic, alpha-2 adrenergic and adenosine receptors are all involved in the antiallodynic effects of tianeptine at the spinal level.

키워드

Adenosine receptor, Alpha-2 adrenergic receptor, Antiallodynia, Neuropathic pain, Serotonin receptor, Tianeptine

KMID : 1155520140090020093

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건강보험코드

신경병증 통증 쥐 척수강 내로 투여한 Tianeptine의 항이질통 효과 Antiallodynic effects of intrathecal tianeptine in a neuropathic pain rat

Abstract

키워드

신경병증 통증 쥐 척수강 내로 투여한 Tianeptine의 항이질통 효과
Antiallodynic effects of intrathecal tianeptine in a neuropathic pain rat