KCTBASE

Survival benefit of taxane plus platinum in recurrent ovarian cancer with non-clear cell, non-mucinous histology

Journal of Gynecologic Oncology 2014년 25권 1호 p.43 ~ p.50

(Kajiyama Hiroaki) - Nagoya University Graduate School of Medicine Department of Obstetrics and Gynecology
(Sekiya Ryuichiro) - Nagoya University Graduate School of Medicine Department of Obstetrics and Gynecology
(Shibata Kiyosumi) - Nagoya University Graduate School of Medicine Department of Obstetrics and Gynecology
(Mizuno Mika) - Nagoya University Graduate School of Medicine Department of Obstetrics and Gynecology
(Umezu Tomokazu) - Nagoya University Graduate School of Medicine Department of Obstetrics and Gynecology
(Suzuki Shiro) - Nagoya University Graduate School of Medicine Department of Obstetrics and Gynecology
(Niimi Kaoru) - Nagoya University Graduate School of Medicine Department of Obstetrics and Gynecology
(Mitsui Hiroko) - Nagoya University Graduate School of Medicine Department of Obstetrics and Gynecology
(Yamamoto Eiko) - Nagoya University Graduate School of Medicine Department of Obstetrics and Gynecology
(Kawai Michiyasu) - Toyohashi Municipal Hospital Department of Obstetrics and Gynecology
(Nagasaka Tetsuro) - Nagoya University Graduate School of Medicine School of Health Science
(Kikkawa Fumitaka) - Nagoya University Graduate School of Medicine School of Health Science

Abstract

Objective: This study was conducted to examine the effects of front-line chemotherapy on overall survival (OS) and postrecurrence survival (PRS) of patients with recurrent ovarian cancer, when stratifying the histologic type.

Methods: Five hundred and seventy-four patients with recurrent ovarian cancer with sufficient clinical information, including front-line chemotherapy, were analyzed. The pathologic slides were evaluated by central pathologic review. The patients were divided into two groups: group A (n=261), who underwent taxane plus platinum, and group B (n=313), who underwent conventional platinum-based chemotherapy without taxanes.

Results: The median age was 54 years (range, 14 to 89 years). Group A had significantly better median OS (45.0 months vs. 30.3 months, p<0.001) and PRS (23.0 months vs. 13.0 months, p<0.001) compared to group B. The OS and PRS were similar between the groups in patients with clear cell or mucinous histology. In contrast, among patients with non-clear cell, non-mucinous histologies, the OS and PRS of group A were significantly better than those of group B (OS, p<0.001; PRS, p<0.001). Multivariable analyses revealed that, among patients with non-clear cell, non-mucinous histologies, chemotherapy including taxane and platinum was an independent predictor of favorable survival outcomes. Conversely, in patients with clear cell or mucinous histology, taxane-including platinum-based combination chemotherapy did not improve the OS and PRS compared to a conventional platinum-based regimen which did not include taxanes.

Conclusion: Since the emergence of taxane plus platinum, the prognosis of patients with recurrent ovarian cancer has improved. However, we here demonstrate that this improvement is limited to patients with non-clear cell, non-mucinous histologies.