Exhaled Breath Analysis System based on Electronic Nose Techniques Applicable to Lung Diseases
Hanyang Medical Reviews 2014³â 34±Ç 3È£ p.125 ~ p.129
º¯Çü±â(Byun Hyung-Gi) - Kangwon National University Division of Electronics, Information & Communication Engineering
(Yu Joon-Boo) - Kyungpook National University Department of Material Science and Metallurgy
(Huh Jeung-Soo) - Kyungpook National University Department of Material Science and Metallurgy
ÀÓÁ¤¿Á(Lim Jeong-Ok) - Kyungpook National University Hospital Biomedical Research Institute
Abstract
Smell used to be a common diagnostic tool in medicine, and physicians were trained to use their sense of smell during their medical training. Latterly, odor disgnostics have been relegated to secondary status as a diagnostic method. Array-based gas sensors (¡°Electronic Nose¡±) now offer the potential of a robust analytical approach to exhaled breath analysis for medical use. Many diseases are accompanied by characteristic odor, and their recognition can provide diagonostic clues, guide the laboratory evaluation, and affect the choice of immediate therapy. We are developing an intelligent sensor system for non-invasive health care monitoring combined laboratory based sensor module, pattern recognition subsystem and non-invasive sampling of volatile emitted from a patient into a highly intelligent sensor system that allows the rapid processing of these samples. It is capable to assist early and rapid disgnosis of changes in state of patient, and aid decision making by medical personnel in the treatment of such patients. In this paper, we introduce exhaled breath analysis for potential primary lung disease screening using electronic nose system incorporating an automated solid-phase microextraction (SPME) desorption to enable the system to be used. Aiming to increase the sensitivity, SPME preconcentration is used for sampling of headspace air and the response of sensor module to variable concentration of volatile emitted from SPME fiber is evaluated. The initial result shows the distinguished difference between the lung cancer patients and healthy normal individuals according to the analysis of the respective expiratory gases.
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Exhalation, Electronic Nose, Lung Diseases, VOCs (Volatile Organic Compounds)
KMID :
1134220140340030125
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