Accelerated Partial Breast Irradiation with Intensity-Modulated Radiotherapy Is Feasible for Chinese Breast Cancer Patients
Journal of Breast Cancer 2014³â 17±Ç 3È£ p.256 ~ p.264
(He Zhen-Yu) - Sun Yat-Sen University Cancer Center Department of Radiation Oncology
(Wu San-Gang) - China The First Affiliated Hospital of Xiamen University Xiamen Cancer Center Department of Radiation Oncology
(Zhou Juan) - China The First Affiliated Hospital of Xiamen University Xiamen Cancer Center Department of Obstetrics and Gynecology
(Li Feng-Yan) - Sun Yat-Sen University Cancer Center Department of Radiation Oncology
(Sun Jia-Yan) - Sun Yat-Sen University Cancer Center Department of Radiation Oncology
(Lin Qin) - Sun Yat-Sen University Cancer Center Department of Radiation Oncology
(Lin Huan-Xin) - Sun Yat-Sen University Cancer Center Department of Radiation Oncology
(Guan Xun-Xing) - Sun Yat-Sen University Cancer Center Department of Radiation Oncology
Abstract
Purpose: Several accelerated partial breast irradiation (APBI) techniques are being investigated in patients with early-stage breast cancer. The present study evaluated the feasibility, early toxicity, initial efficacy, and cosmetic outcomes of accelerated partial breast intensity-modulated radiotherapy (IMRT) for Chinese female patients with early-stage breast cancer after breast-conserving surgery.
Methods: A total of 38 patients met the inclusion criteria and an accelerated partial breast intensity-modulated radiotherapy (APBI-IMRT) plan was designed for each patient. The prescription dose was 34 Gy in 10 fractions, 3.4 Gy per fraction, twice a day, in intervals of more than 6 hours.
Results: Of the 38 patients, six patients did not meet the planning criteria. The remaining 32 patients received APBI-IMRT with a mean target volume conformity index of 0.67 and a dose homogeneity index of 1.06. The median follow-up time was 53 months and no local recurrence or distant metastasis was detected. The most common acute toxicities observed within 3 months after radiotherapy were erythema, breast edema, pigmentation, and pain in the irradiated location, among which 43.8%, 12.5%, 31.3%, and 28.1% were grade 1 toxicities, respectively. The most common late toxicities occurring after 3 months until the end of the follow-up period were breast edema, pigmentation, pain in the irradiated location, and subcutaneous fibrosis, among which 6.2%, 28.1%, 21.9%, and 37.5% were grade 1 toxicities, respectively. Thirty-one patients (96.8%) had fine or excellent cosmetic outcomes, and only one patient had a poor cosmetic outcome.
Conclusion: It is feasible for Chinese females to receive APBI-IMRT after breast conserving surgery. The radiotherapeutic toxicity is acceptable, and both the initial efficacy and cosmetic outcomes are good.
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Breast neoplasms, Intensity-modulated radiotherapy, Segmental mastectomy
KMID :
1134120140170030256
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