A Pilot Randomized Clinical Study of the Additive Treatment Effect of Photodynamic Therapy in Breast Cancer Patients with Chest Wall Recurrence
Journal of Breast Cancer 2014³â 17±Ç 2È£ p.161 ~ p.166
(Liu Yan) - Tianjin Medical University Cancer Institute and Hospital National Clinical Research Center of Cancer Department of Breast Cancer
(Hou Guo-Fang) - Tianjin Medical University Cancer Institute and Hospital National Clinical Research Center of Cancer Department of Breast Cancer
(Zhang Xiao-Bei) - Tianjin Medical University Cancer Institute and Hospital National Clinical Research Center of Cancer Department of Breast Cancer
(Liu Jing-Jing) - Tianjin Medical University Cancer Institute and Hospital National Clinical Research Center of Cancer Department of Breast Cancer
(Zhang Sheng) - Tianjin Medical University Cancer Institute and Hospital National Clinical Research Center of Cancer Department of Breast Cancer
(Zhang Jin) - Tianjin Medical University Cancer Institute and Hospital National Clinical Research Center of Cancer Department of Breast Cancer
Abstract
Purpose: This study investigated the additive effect of photodynamic therapy (PDT) plus traditional radiotherapy (RT) for patients with breast cancer and chest wall recurrence.
Methods: A total of 40 patients with recurrent breast cancer were prospectively randomized to receive RT alone (group A, n=20) or PDT and RT in combination (group B, n=20). Traditional RT at a dose of 50 Gy was delivered in 25 fractions with or without exposure to 5-aminolevulinic acid and red light as PDT.
Results: The response rates were not statistically different between the groups, but more patients achieved a complete response (CR) in group B (50%) than in group A (20%). The median time to CR in group B was significantly shorter than that in group A (109.6 days vs. 175.2 days, p=0.001). Adverse event profiles were not different between the groups.
Conclusion: An additive antitumor effect is demonstrated with additional PDT to RT. This combination therapy might reduce the duration of exposure to RT, but further investigation is warranted.
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Breast neoplasms, Photochemotherapy, Recurrence, Thoracic wal
KMID :
1134120140170020161
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