Characteristics of BRCA1/2 Mutation-Positive Breast Cancers in Korea: A Comparison Study Based on Multicenter Data and the Korean Breast Cancer Registry
Journal of Breast Cancer 2014³â 17±Ç 2È£ p.129 ~ p.135
À¯Á¾ÇÑ(Yu Jong-Han) - University of Ulsan College of Medicine Asan Medical Center Department of Surgery
ÀÌÁ¾¿ø(Lee Jong-Won) - University of Ulsan College of Medicine Asan Medical Center Department of Surgery
¼Õº´È£(Son Byung-Ho) - University of Ulsan College of Medicine Asan Medical Center Department of Surgery
±è¼º¿ø(Kim Sung-Won) - Seoul National University Bundang Hospital Department of Surgery
(Park Sue-K.) - Seoul National University College of Medicine Department of Preventive Medicine
À̹ÎÇõ(Lee Min-Hyuk) - Soonchunhyang University Hospital Department of Surgery
±èÀ̼ö(Kim Lee-Su) - Hallym University College of Medicine Hallym University Sacred Heart Hospital Department of Surgery
³ë¿ìö(Noh Woo-Chul) - Korea Cancer Center Hospital Department of Surgery
±èÀº±Ô(Kim Eun-Kyu) - Korea Cancer Center Hospital Department of Surgery
À±´ë¼º(Yoon Dae-Sung) - Konyang University College of Medicine Konyang University Hospital Department of Surgery
ÀÌÁö¿¬(Lee Jee-Yeon) - Pusan National University Hospital Department of Surgery
Á¤ÁøÇâ(Jung Jin-Hyang) - Kyungpook National University School of Medicine Kyungpook National University Hospital Department of Surgery
Á¤»ó¼³(Jung Sang-Seol) - Catholic University College of Medicine Seoul St. Mary¡¯s Hospital Department of Surgery
°ø°æ¿±(Gong Gyung-Yup) - University of Ulsan College of Medicine Asan Medical Center Department of Pathology
¾È¼¼Çö(Ahn Sei-Hyun) - University of Ulsan College of Medicine Asan Medical Center Department of Surgery
Abstract
Purpose: Mutations in BRCA genes are the main cause of hereditary breast cancer in Korea. The aim of this study was to investigate the characteristics of breast cancers involving BRCA1 (BRCA1 group) and BRCA2 (BRCA2 group) mutations.
Methods: We retrospectively reviewed the medical records of patients with BRCA1 (BRCA1 group) or BRCA2 (BRCA2 group) mutation positive breast cancer from multiple centers and compared the data to that of the Korean Breast Cancer Society registry (registry group).
Results: The patients of the BRCA1 group were diagnosed at a younger age (median age, 37 years) and had tumors of higher histological (61.3% with histological grade 3) and nuclear (37.5% with nuclear grade 3) grade than those of the registry group. In addition, the frequency of ductal carcinoma in situ in the BRCA1 group was lower (3.7%) than in the registry group, and the BRCA1 group were more likely to be triple-negative breast cancer (61.3%). Patients in the BRCA2 group were also younger at diagnosis (mean age, 41 years) and were more likely to have involvement of the axillary node than the registry group (45.5% vs. 33.5%, p=0.002). The BRCA1 and BRCA2 groups did not show a correlation between tumor size and axillary node involvement.
Conclusion: We report the characteristics of BRCA mutation positive breast cancer patients in the Korean population through multicenter data and nation-wide breast cancer registry study. However, BRCA-mutated breast cancers appear highly complex, and further research on their molecular basis is needed in Korea.
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BRCA1 genes, BRCA2 genes, Breast neoplasms, Korea
KMID :
1134120140170020129
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