Sleep Problems Associated with Behavioral and Psychological Symptoms as Well as Cognitive Functions in Alzheimer¡¯s Disease
Journal of Clinical Neurology 2014³â 10±Ç 3È£ p.203 ~ p.209
½ÅÇý¿µ(Shin Hye-Young) - Gachon University Gil Medical Center Department of Neurology
ÇÑÇöÁ¤(Han Hyun-Jung) - Myongji Hospital Department of Neurology
½Åµ¿Áø(Shin Dong-Jin) - Gachon University Gil Medical Center Department of Neurology
¹ÚÇö¹Ì(Park Hyeon-Mi) - Gachon University Gil Medical Center Department of Neurology
ÀÌ¿µ¹è(Lee Yeong-Bae) - Gachon University Gil Medical Center Department of Neurology
¹Ú±âÇü(Park Kee-Hyung) - Gachon University Gil Medical Center Department of Neurology
Abstract
Background and Purpose: It has been shown that sleep problems in Alzheimer¡¯s disease (AD) are associated with cognitive impairment and behavioral problems. In fact, most of studies have founded that daytime sleepiness is significantly correlated with cognitive decline in AD. However, a few studies have also shown that nighttime sleep problems are associated with cognitive function and behavioral symptoms in AD. Accordingly, the aim of this study was to evaluate the effects of nighttime sleep on cognition and behavioral and psychological symptoms of dementia (BPSD) in AD.
Methods: The study population comprised 117 subjects: 63 AD patients and 54 age- and sex-matched non-demented elderly subjects. Detailed cognitive functions and behavioral symptoms were measured using the Seoul Neuropsychological Screening Battery (SNSB) and the Korean version of the Neuropsychiatric Inventory (NPI-K). Sleep characteristics were evaluated using the Korean version of the Pittsburgh Sleep Quality Index (PSQI-K). The correlations between PSQI-K and SNSB scores and between PSQI-K and NPI-K scores were analyzed.
Results: In AD patients, sleep latency was found to be negatively correlated with praxis (p=0.041), Rey-Osterrieth Complex Figure Test (RCFT) immediate recall (p=0.041), and RCFT recognition (p=0.008) after controlling for age and education, while sleep duration and sleep efficiency were positively correlated with praxis (p=0.034 and p=0.025, respectively). Although no significant correlation was found between PSQI-K and NPI-K scores, sleep disturbance and total PSQI-K scores were found to be significantly associated with apathy/indifference in AD.
Conclusions: Sleep problems such as prolonged sleep duration, sleep latency, and poor sleep efficiency in AD patients were correlated with cognitive dysfunction, and especially frontal executive and visuospatial functions, and BPSD. These findings suggest that treatment of nighttime sleep problems might improve cognition and behavioral symptoms in AD patients.
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sleep, cognition, behavioral symptoms, Alzheimer¡¯s disease
KMID :
1130620140100030203
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