T2 Relaxometry Using 3.0-Tesla Magnetic Resonance Imaging of the Brain in Early- and Late-Onset Restless Legs Syndrome
Journal of Clinical Neurology 2014³â 10±Ç 3È£ p.197 ~ p.202
¹®ÇýÁø(Moon Hye-Jin) - Keimyung University School of Medicine Dongsan Medical Center Department of Neurology
Àå¿ë¹Î(Chang Yong-Min) - Kyungpook National University Hospital Department of Molecular Medicine
ÀÌ¿µ¼±(Lee Yeong-Seon) - Keimyung University School of Medicine Dongsan Medical Center Department of Neurology
¼ÛÈñÁø(Song Hee-Jin) - Keimyung University School of Medicine Dongsan Medical Center Department of Neurology
ÀåÇõ¿ø(Chang Hyuk-Won) - Keimyung University School of Medicine Dongsan Medical Center Department of Radiology
±¸Á¤ÈÆ(Ku Jeong-Hun) - Keimyung University School of Medicine Dongsan Medical Center Department of Biomedical Engineering
Á¶¿ë¿ø(Cho Yong-Won) - Keimyung University School of Medicine Dongsan Medical Center Department of Neurology
Abstract
Background and Purpose: Previous T2 relaxometry studies have provided evidence for regional brain iron deficiency in patients with restless legs syndrome (RLS). Measurement of the iron content in several brain regions, and in particular the substantia nigra (SN), in early- and late-onset RLS patients using T2 relaxometry have yielded inconsistent results. In this study the regional iron content was assessed in patients with early- and late-onset RLS using magnetic resonance imaging (MRI), and compared the results with those in controls.
Methods: Thirty-seven patients with idiopathic RLS (20 with early onset and 17 with late onset) and 40 control subjects were studied using a 3.0-tesla MRI with a gradient-echo sampling of free induction decay and echo pulse sequence. The regions of interest in the brain were measured independently by two trained analysts using software known as medical image processing, analysis, and visualization. The results were compared and a correlation analysis was conducted to investigate which brain areas were related to RLS clinical variables.
Results: The iron index in the SN was significantly lower in patients with late-onset RLS than in controls (p=0.034), while in patients with early-onset RLS there was no significant difference. There was no significant correlation between the SN iron index of the late-onset RLS group and clinical variables such as disease severity.
Conclusions: Late-onset RLS is associated with decreased iron content in the SN. This finding supports the hypothesis that regional brain iron deficiency plays a role in the pathophysiology of late-onset RLS.
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restless legs syndrome, T2 relaxometry, red nucleus, substantia nigra, iron
KMID :
1130620140100030197
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