Prevalence of Anti-Ganglioside Antibodies and Their Clinical Correlates with Guillain-Barre Syndrome in Korea: A Nationwide Multicenter Study
Journal of Clinical Neurology 2014³â 10±Ç 2È£ p.94 ~ p.100
±èÁ¾±¹(Kim Jong-Kuk) - Dong-A University College of Medicine Department of Neurology
¹èÁ¾¼®(Bae Jong-Seok) - Hallym University College of Medicine Department of Neurology
±è´ë¼º(Kim Dae-Seong) - Pusan National University School of Medicine Department of Neurology
(Kusunoki Susumu) - Japan Kinki University School of Medicine Department of Neurology
±èÁ¾Àº(Kim Jong-Eun) - Pusan National University School of Medicine Department of Industrial and Occupational Medicine
±èÁö¼ö(Kim Ji-Soo) - Seoul National University College of Medicine Department of Neurology
¹Ú¿µÀº(Park Young-Eun) - Pusan National University School of Medicine Department of Neurology
¹Ú±âÁ¾(Park Ki-Jong) - Gyeongsang National University School of Medicine Department of Neurology
¼ÛÇö¼®(Song Hyun-Seok) - Kyungpook National University School of Medicine Department of Neurology
±è¼±¿µ(Kim Sun-Young) - University of Ulsan College of Medicine Department of Neurology
ÀÓÁ¤±Ù(Lim Jeong-Geun) - Keimyung University School of Medicine Department of Neurology
±è³²Èñ(Kim Nam-Hee) - Dongguk University College of Medicine Department of Neurology
¼¹üõ(Suh Bum-Chun) - Sungkyunkwan University School of Medicine Department of Neurology
³²Å½Â(Nam Tai-Seung) - Chonnam National University Medical School Department of Neurology
¹Ú¹Î¼ö(Park Min-Su) - Yeungnam University School of Medicine Department of Neurology
ÃÖ¿µÃ¶(Choi Young-Chul) - Yonsei University College of Medicine Department of Neurology
¼ÕÀºÈñ(Sohn Eun-Hee) - Chungnam National University School of Medicine Department of Neurology
³ª»óÁØ(Na Sang-Jun) - Konyang University College of Medicine Department of Neurology
Çã¼Ò¿µ(Huh So-Young) - Kosin University College of Medicine Department of Neurology
±Ç¿ÀÇö(Kwon O-Hyun) - Eulji University School of Medicine Department of Neurology
À̼ö¿¬(Lee Su-Yun) - Dong-A University College of Medicine Department of Neurology
À̼ºÈÆ(Lee Sung-Hoon) - Hallym University College of Medicine Department of Neurology
¿À¼±¿µ(Oh Sun-Young) - Jeonbuk National University School of Medicine Department of Neurology
Á¤¼ºÇØ(Jeong Seong-Hae) - Chungnam National University School of Medicine Department of Neurology
ÀÌÅ°æ(Lee Tae-Kyeong) - Soonchunhyang University College of Medicine Department of Neurology
±èµ¿¿í(Kim Dong-Uk) - Chosun University School of Medicine Department of Neurology
Abstract
Background and Purpose: No previous studies have investigated the relationship between various anti-ganglioside antibodies and the clinical characteristics of Guillain-Barre syndrome (GBS) in Korea. The aim of this study was to determine the prevalence and types of anti-ganglioside antibodies in Korean GBS patients, and to identify their clinical significance.
Methods: Serum was collected from patients during the acute phase of GBS at 20 university-based hospitals in Korea. The clinical and laboratory findings were reviewed and compared with the detected types of anti-ganglioside antibody.
Results: Among 119 patients, 60 were positive for immunoglobulin G (IgG) or immunoglobulin M antibodies against any type of ganglioside (50%). The most frequent type was IgG anti-GM1 antibody (47%), followed by IgG anti-GT1a (38%), IgG anti-GD1a (25%), and IgG anti-GQ1b (8%) antibodies. Anti-GM1-antibody positivity was strongly correlated with the presence of preceding gastrointestinal infection, absence of sensory symptoms or signs, and absence of cranial nerve involvement. Patients with anti-GD1a antibody were younger, predominantly male, and had more facial nerve involvement than the antibody-negative group. Anti-GT1a-antibody positivity was more frequently associated with bulbar weakness and was highly associated with ophthalmoplegia when coupled with the coexisting anti-GQ1b antibody. Despite the presence of clinical features of acute motor axonal neuropathy (AMAN), 68% of anti-GM1- or anti-GD1a-antibody-positive cases of GBS were diagnosed with acute inflammatory demyelinating polyradiculoneuropathy (AIDP) by a single electrophysiological study.
Conclusions: Anti-ganglioside antibodies were frequently found in the serum of Korean GBS patients, and each antibody was correlated strongly with the various clinical manifestations. Nevertheless, without an anti-ganglioside antibody assay, in Korea AMAN is frequently misdiagnosed as AIDP by single electrophysiological studies.
Å°¿öµå
Guillain-Barre syndrome, ganglioside, antibodies, Korea, acute motor axonal neuropathy
KMID :
1130620140100020094
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