Prevalence of respiratory viral infection in children hospitalized for acute lower respiratory tract diseases, and association of rhinovirus and influenza virus with asthma exacerbations
Korean Journal of Pediatrics 2014³â 57±Ç 1È£ p.29 ~ p.34
±ÇÀå¹Ì(Kwon Jang-Mi) - Sungkyunkwan University School of Medicine Kangbuk Samsung Hospital Department of Pediatrics
½ÉÀç¿ø(Shim Jae-Won) - Sungkyunkwan University School of Medicine Kangbuk Samsung Hospital Department of Pediatrics
±è´ö¼ö(Kim Deok-Soo) - Sungkyunkwan University School of Medicine Kangbuk Samsung Hospital Department of Pediatrics
Á¤Çý¸²(Jung Hye-Lim) - Sungkyunkwan University School of Medicine Kangbuk Samsung Hospital Department of Pediatrics
¹Ú¹®¼ö(Park Moon-Soo) - Sungkyunkwan University School of Medicine Kangbuk Samsung Hospital Department of Pediatrics
½ÉÁ¤¿¬(Shim Jung-Yeon) - Sungkyunkwan University School of Medicine Kangbuk Samsung Hospital Department of Pediatrics
Abstract
Purpose:In this study, we aimed to investigate the prevalence of year-round respiratory viral infection in children with lower respiratory tract infection (LRTI) and the relationship between respiratory viral infection and allergen sensitization in exacerbating asthma.
Methods:We investigated the sources for acute LRTIs in children admitted to our hospital from May 2010 to April 2011. The 6 most common respiratory viruses were isolated from nasopharyngeal aspirate using multiplex reverse transcription-polymerase chain reaction in 309 children; respiratory syncytial virus (RSV), adenovirus (AV), parainfluenza virus (PIV), influenza virus (IFV), human metapneumovirus (hMPV), rhinovirus (RV). Atopic sensitization was defined if more than 1 serum specific Immunoglobulin E level measured using UniCAP (Pharmacia) was over 0.35 IU/mL.
Results:RSV was the most common pathogen of bronchiolitis in hospitalized children through the year. RV or IFV infection was more prevalent in asthma exacerbations compared to other LRTIs. AV and hMPV were more likely to cause pneumonia. RV and IFV were associated with asthma exacerbations in children with atopic sensitization, but not in nonatopic children.
Conclusion:RV and IFV are associated with hospitalization for asthma exacerbation in children with atopic sensitization.
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Asthma, Allergens, Child, Orthomyxoviridae, Rhinovirus
KMID :
1130320140570010029
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