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Qu-Ji-Du-Huang-Wan for Essential Hypertension : Systemic Review and Meta-analysis
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ÇÑÀνÄ(Han In-Sik) - »óÁö´ëÇб³ ÇÑÀÇ°ú´ëÇÐ Çѹ泻°ú
½ÅÁöÇý(Shin Ji-Hye) - »óÁö´ëÇб³ ÇÑÀÇ°ú´ëÇÐ Çѹ泻°úÇб³½Ç
Á¶À±¿µ(Cho Yoon-Young) - »óÁö´ëÇб³ ÇÑÀÇ°ú´ëÇÐ Çѹ泻°úÇб³½Ç
¹ÚÇظð(Park Hae-Mo) - »óÁö´ëÇб³ ÇÑÀÇ°ú´ëÇÐ ¿¹¹æÀÇÇб³½Ç
¾çâ¼·(Yang Chang-Sop) - Çѱ¹ÇÑÀÇÇבּ¸¿ø Àӻ󿬱¸ºÎ
Á¤ÁÖÈñ(Jeong Ju-Hui) - ¿ì¼®´ëÇб³ ÇÑÀÇ°ú´ëÇÐ Çѹæ¼Ò¾Æ°úÇб³½Ç
ÀåÀμö(Jang In-Soo) - ¿ì¼®´ëÇб³ ÇÑÀÇ°ú´ëÇÐ Çѹ泻°úÇб³½Ç
¼±½ÂÈ£(Sun Seung-Ho) - »óÁö´ëÇб³ ÇÑÀÇ°ú´ëÇÐ Çѹ泻°úÇб³½Ç
Abstract
The purpose of this study is to investigate the blood pressure reducing effect of Qi-Ju-Di-Huang-Wan (QJDHW) in adults with essential hypertension by using methods of systemic review and meta-analysis. Major search engines, such as PubMed, EMBASE, Cochrane library, Web of Science, CNKI, CiNii, J-STAGE, KISS, NDSL, RISS, OASIS, DBpia and so on, were used. The search period we used is from the start date of the search engine to October 30, 2016 and no language limits were placed. Randomized controlled trials using QJDHW in adults with essential hypertension were searched and extracted by two independent researchers. Meta-analysis was performed on outcome variables of the total effective rate (TER), systolic blood pressure (SBP) and diastolic blood pressure (DBP). Risk of bias (RoB) of Cochrane was used to assess methodological quality. Thirteen studies were finally selected. We observed that the combined treatment of QJDHW and antihypertensive drug had 3.6 times the odds ratio of TER for blood pressure lowering than a single use of an antihypertensive drug. Additionally, mean differences of SBP and DBP were -8.88 mmHg (95% Confidential Interval (CI) -12.77 mmHg, -5.00 mmHg, P<0.00001), -7.09 mmHg (95% CI -9.93, -4.25, P <0.00001), respectively. Single use of QJDHW did not reduce blood pressure more than an antihypertensive drug. All items of RoB were unclear and the methodological quality was low. Our analysis suggests that the combination of QJDHW and antihypertensive drugs may be more effective in reducing blood pressure than a single antihypertensive drug. But due to low methodological quality, careful interpretation will be needed and systematic long-term clinical trials will be required.
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Herbal medicine, Hypertension, Systemic review, Meta-analysis, Qu-Ji-Du-Huang-Wan
KMID :
1123920170310020118
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À¯È¿¼º°á°ú(Recomendation)
The combination of QJDHW and antihypertensive drugs may be more effective in reducing blood pressure than a single antihypertensive drug.