Epistatic Interactions between CREB and CREM Variants in Affective Disorder
Psychiatry Investigation 2014³â 11±Ç 2È£ p.200 ~ p.203
(Chiesa Alberto) - University of Bologna Department of Biomedical and NeuroMotor Sciences
(Marsano Agnese) - University of Bologna Department of Biomedical and NeuroMotor Sciences
ÇÑâ¼ö(Han Chang-Su) - Korea University College of Medicine Department of Psychiatry
À̼öÁ¤(Lee Soo-Jung) - Catholic University College of Medicine Bucheon St. Mary¡¯s Hospital Department of Psychiatry
(Patkar Ashwin A) - Duke University Medical Center Department of Psychiatry and Behavioral Sciences
¹èÁöÀº(Pae Chi-Un) - Catholic University College of Medicine Bucheon St. Mary¡¯s Hospital Department of Psychiatry
(Serretti Alessandro) - University of Bologna Department of Biomedical and NeuroMotor Sciences
Abstract
The aim of the present work is to investigate the existence of epistatic interactions possibly influencing psychotropic agents¡¯ response between rs6740584 within Cyclic adenosine monophosphate Response Element Binding (CREB) and rs12775799 within cAMP response element-modulator (CREM) variants in bipolar disorder (BD) and major depressive disorder (MDD). All BD and MDD patients were administered with the Young Mania Rating Scale (YMRS) and Hamilton Depression Rating Scale (HAMD) at baseline and at endpoint, respectively. A multiple regression model was employed to investigate the existence of possible epistatic interactions between the two variants and diverse clinical factors including drug response in affective disorders. No significant epistatic interaction was observed between rs6740584 within CREB and rs12775799 within CREM on both symptom improvement and other clinical factors in affective disorders. Our preliminary results suggest that no epistatic interaction between rs6740584 within CREB and rs12775799 within CREM should exist on clinical improvement and clinical factors in affective disorders.
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CREB, CREM, Epistasis, Response affective disorder
KMID :
1118520140110020200
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