A Disrupted-in-Schizophrenia 1 Gene Variant is Associated with Clinical Symptomatology in Patients with First-Episode Psychosis
Psychiatry Investigation 2014³â 11±Ç 2È£ p.186 ~ p.191
(Vazquez-Bourgon Javier) - University of Cantabria School of Medicine University Hospital Marques de Valdecilla-IFIMAV Department of Psychiatry
(Mata Ignacio) - Centro de Investigacion Biomedica en Red de Salud Mental
(Roiz-Santianez Roberto) - University of Cantabria School of Medicine University Hospital Marques de Valdecilla-IFIMAV Department of Psychiatry
(Ayesa-Arriola Rosa) - University of Cantabria School of Medicine University Hospital Marques de Valdecilla-IFIMAV Department of Psychiatry
(Pinilla Paula Suarez) - University of Cantabria School of Medicine University Hospital Marques de Valdecilla-IFIMAV Department of Psychiatry
(Tordesillas-Gutierrez Diana) - University of Cantabria School of Medicine University Hospital Marques de Valdecilla-IFIMAV Department of Psychiatry
(Vazquez-Barquero Jose Luis) - University of Cantabria School of Medicine University Hospital Marques de Valdecilla-IFIMAV Department of Psychiatry
(Crespo-Facorro Benedicto) - University of Cantabria School of Medicine University Hospital Marques de Valdecilla-IFIMAV Department of Psychiatry
Abstract
Objective: DISC1 gene is one of the main candidate genes for schizophrenia since it has been associated to the illness in several populations. Moreover, variations in several DISC1 polymorphisms, and in particular Ser704Cys SNP, have been associated in schizophrenic patients to structural and functional modifications in two brain areas (pre-frontal cortex and hippocampus) that play a central role in the genesis of psychotic symptoms. This study tested the association between Ser704Cys DISC1 polymorphism and the clinical onset of psychosis.
Methods: Two hundred and thirteen Caucasian drug-naive patients experiencing a first episode of non-affective psychosis were genotyped for rs821616 (Ser704Cys) SNP of the DISC1 gene. The clinical severity of the illness was assessed using SAPS and SANS scales. Other clinical and socio-demographic variables were recorded to rule out possible confounding effects.
Results: Patients homozygous for the Ser allele of the Ser704Cys DISC1 SNP had significantly (p<0.05) higher rates at the positive symptoms dimension (SAPS-SANS scales) and hallucinations item, compared to Cys carriers.
Conclusion: DISC1 gene variations may modulate the clinical severity of the psychosis at the onset of the disorder.
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DISC1 ser704cys, Genetics, Hallucinations, Schizophrenia, Severity of illness
KMID :
1118520140110020186
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