Low-Dose Acetazolamide in the Treatment of Premenstrual Dysphoric Disorder: A Case Series
Psychiatry Investigation 2014³â 11±Ç 1È£ p.95 ~ p.101
(Sani Gabriele) - Sapienza University School of Medicine and Psychology Sant¡¯Andrea Hospital Department of NESMOS
(Kotzalidis Georgios D) - Sapienza University School of Medicine and Psychology Sant¡¯Andrea Hospital Department of NESMOS
(Panaccione Isabella) - Sapienza University School of Medicine and Psychology Sant¡¯Andrea Hospital Department of NESMOS
(Simonetti Alessio) - Sapienza University School of Medicine and Psychology Sant¡¯Andrea Hospital Department of NESMOS
(Chiara Lavinia De) - Sapienza University School of Medicine and Psychology Sant¡¯Andrea Hospital Department of NESMOS
(Casale Antonio Del) - Sapienza University School of Medicine and Psychology Sant¡¯Andrea Hospital Department of NESMOS
(Ambrosi Elisa) - Sapienza University School of Medicine and Psychology Sant¡¯Andrea Hospital Department of NESMOS
(Napoletano Flavia) - Sapienza University School of Medicine and Psychology Sant¡¯Andrea Hospital Department of NESMOS
(Janiri Delfina) - Sapienza University School of Medicine and Psychology Sant¡¯Andrea Hospital Department of NESMOS
(Danese Emanuela) - Sapienza University School of Medicine and Psychology Sant¡¯Andrea Hospital Department of NESMOS
(Girardi Nicoletta) - Sapienza University School of Medicine and Psychology Sant¡¯Andrea Hospital Department of NESMOS
(Rapinesi Chiara) - Sapienza University School of Medicine and Psychology Sant¡¯Andrea Hospital Department of NESMOS
(Serata Daniele) - Sapienza University School of Medicine and Psychology Sant¡¯Andrea Hospital Department of NESMOS
(Manfredi Giovanni) - Sapienza University School of Medicine and Psychology Sant¡¯Andrea Hospital Department of NESMOS
(Koukopoulos Alexia E) - Sapienza University School of Medicine and Psychology Sant¡¯Andrea Hospital Department of NESMOS
(Angeletti Gloria) - Sapienza University School of Medicine and Psychology Sant¡¯Andrea Hospital Department of NESMOS
(Nicoletti Ferdinando) - IRCSS NEUROMED
(Girardi Paolo) - Sapienza University School of Medicine and Psychology Sant¡¯Andrea Hospital Department of NESMOS
Abstract
The treatment of premenstrual dysphoric disorder (PMDD) is far from satisfactory, as there is a high proportion of patients who do not respond to conventional treatment. The antidiuretic sulfonamide, acetazolamide, inhibits carbonic anhydrase and potentiates GABAergic transmission; the latter is putatively involved in PMDD. We therefore tried acetazolamide in a series of women with intractable PMDD. Here, we describe a series of eight women diagnosed with DSM-IV-TR PMDD, five of whom had comorbidity with a mood disorder and one with an anxiety disorder, who were resistant to treatment and responded with symptom disappearance after being added-on 125 mg/day acetazolamide for 7-10 days prior to menses each month. Patients were free from premenstrual symptoms at the 12-month follow-up. We suggest that acetazolamide may be used to improve symptoms of PMDD in cases not responding to other treatments. GABAergic mechanisms may be involved in counteracting PMDD symptoms.
Å°¿öµå
Premenstrual dysphoric disorder, Sulfonamide diuretics, Acetazolamide, GABA transmission
KMID :
1118520140110010095
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