No association between the IL28B SNP and response to peginterferon plus ribavirin combination treatment in Korean chronic hepatitis C patients
Korean Journal of Hepatology 2014³â 20±Ç 2È£ p.177 ~ p.184
Çã³»À±(Heo Nae-Yun) - Inje University College of Medicine Haeundae Paik Hospital Department of Internal Medicine
ÀÓ¿µ¼®(Lim Young-Suk) - University of Ulsan College of Medicine Asan Medical Center Department of Gastroenterology
ÀÌ¿ìâ(Lee Woo-Chang) - University of Ulsan College of Medicine Asan Medical Center Department of Laboratory Medicine
¿À¹Î°æ(Oh Min-Kyung) - Inje University College of Medicine Busan Paik Hosptial Department of Pharmacology
¾ÈÁöÀ±(An Ji-Yun) - University of Ulsan College of Medicine Asan Medical Center Department of Gastroenterology
À̴ܺñ(Lee Dan-Bi) - University of Ulsan College of Medicine Asan Medical Center Department of Gastroenterology
½ÉÁÖÇö(Shim Ju-Hyun) - University of Ulsan College of Medicine Asan Medical Center Department of Gastroenterology
±è°¸ð(Kim Kang-Mo) - University of Ulsan College of Medicine Asan Medical Center Department of Gastroenterology
ÀÌÇÑÁÖ(Lee Han-Chu) - University of Ulsan College of Medicine Asan Medical Center Department of Gastroenterology
ÀÌ¿µ»ó(Lee Yung-Sang) - University of Ulsan College of Medicine Asan Medical Center Department of Gastroenterology
¼µ¿Áø(Suh Dong-Jin) - University of Ulsan College of Medicine Asan Medical Center Department of Gastroenterology
Abstract
Background/Aims: There are few available data regarding the association between the single nucleotide polymorphisms (SNPs) of the gene encoding interleukin 28B (IL28B) and a sustained virologic response (SVR) to peginterferon (PEG-IFN) plus ribavirin (RBV) therapy in Korean chronic hepatitis C patients.
Methods: This was a retrospective cohort study of 156 patients with chronic hepatitis C virus (HCV) infection who received combination treatment of PEG-IFN plus RBV. Blood samples from these patients were analyzed to identify the IL28B SNPs at rs12979860, rs12980275, rs8099917, and rs8103142. Association analyses were performed to evaluate the relationships between each IL28B SNP and SVRs.
Results: Seventy six patients with HCV genotype 1 and 80 with genotype non-1 were enrolled. The frequencies of rs12979860 CC and CT genotypes were 90.4% and 9.6%, respectively; those of rs12980275 AA and AG genotypes were 87.2% and 12.8%, respectively; those of rs8099917 TT and TG genotypes were 92.3% and 7.7%, respectively; and those of rs8103142 TT and CT genotypes were 90.4% and 9.6%, respectively. Among the patients with HCV genotype 1, the SVR rates were 69.7% and 80.0% for rs12979860 CC and CT, respectively (P=0.71). Among the HCV genotype non-1 patients, SVR rates were 88.0% and 100% for rs12979860 CC and CT (P=1.00), respectively.
Conclusions: Genotypes of the IL28B SNP that are known to be favorable were present in most of the Korean patients with chronic hepatitis C in this study. Moreover, the IL28B SNP did not influence the SVR rate in either the HCV genotype 1 or non-1 patients. Therefore, IL28B SNP analysis might be not useful for the initial assessment, prediction of treatment outcomes, or treatment decision-making of Korean chronic hepatitis C patients.
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Chronic Hepatitis C, Interleukin 28B, Polymorphism, Single Nucleotide, Korean
KMID :
1103920140200020177
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