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초기 알츠하이머병 환자의 호모시스테인 수준과 기억력의 관계
The Relationships between Homocysteine Levels and Memory in Early Alzheimer’s Disease Patients

Dementia and Neurocognitive Disorders 2014년 13권 2호 p.42 ~ p.45

박종식(Park Jong-Sik) - 가톨릭대학교 인천성모병원 신경과
송인욱(Song In-Uk) - 가톨릭대학교 인천성모병원 신경과
정성우(Chung Sung-Woo) - 가톨릭대학교 인천성모병원 신경과
강연욱(Kang Yeon-Wook) - 한림대학교 성심병원 신경과
양영순(Yang Yung-Soon) - 보훈공단 중앙보훈병원 신경과

Abstract

Background: Alzheimer’s disease (AD) is a representative neurodegenerative disorder associated with memory disturbance. Recent research has shown that risk factors for cerebrovascular disorders are also causes of dementia. Of these risk factors, hyperhomocysteinemia is well known to be positively correlated with all types of dementias including AD. But it is not clear if there is a difference in the concentration of homocysteine according to subtypes of memory impairment of AD. We performed this study to explore the relationship between homocysteine and memory.

Methods: A total of 54 patients (male: 15 patients) to the dementia clinic at our hospital were recruited for this study. All subjects underwent neuropsychological tests including detailed memory function tests and brain magnetic resonance images. The plasma homocysteine level was measured routinely in all patients.

Results: Verbal and visual memories in AD ware significantly associated with the concentration of plasma homocysteine. The plasma homocysteine level was significantly correlated with delayed recalls of verbal and visual memories and recognition of visual memory. However, there was no relationship between plasma homocysteine and working memory.

Conclusions: This study showed that plasma homocysteine level was related to the consolidation and retrieval stage of memory in AD. Therefore, we cautiously assumed that control of plasma homocysteine level could contribute to management for the prevention of cognitive impairment.

키워드

Alzheimer’s disease, Memory, Homocysteine

KMID : 1100220140130020042

원문 및 링크아웃 정보

등재저널 정보

주제코드

주제명(Target field)

연구대상(Population)

연구참여(Sample size)

대상성별(Gender)

질병특성(Condition Category)

연구환경(Setting)

연구설계(Study Design)

연구기간(Period)

중재방법(Intervention Type)

중재명칭(Intervention Name)

키워드(Keyword)

유효성결과(Recomendation)

연구비지원(Fund Source)

근거수준평가(Evidence Hierarchy)

출판년도(Year)

참여저자수(Authors)

대표저자

DOI

KCD코드

ICD 03

건강보험코드

초기 알츠하이머병 환자의 호모시스테인 수준과 기억력의 관계 The Relationships between Homocysteine Levels and Memory in Early Alzheimer’s Disease Patients

Abstract

키워드

초기 알츠하이머병 환자의 호모시스테인 수준과 기억력의 관계
The Relationships between Homocysteine Levels and Memory in Early Alzheimer’s Disease Patients