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초기 다계통위축증에 대한 뇌관류 Single Photon Emission Computed Tomography의 임상적 유용성
Clinical Usefulness of 99mTc-Hexamethyl Propylene Amine Oxime Perfusion Single Photon Emission Computed Tomography for Early Phase Multiple System Atrophy

Dementia and Neurocognitive Disorders 2014년 13권 2호 p.37 ~ p.41

이종윤(Lee Jong-Yoon) - 가톨릭대학교 의과대학 신경과학교실
송인욱(Song In-Uk) - 가톨릭대학교 의과대학 신경과학교실
정성우(Chung Sung-Woo) - 가톨릭대학교 의과대학 신경과학교실
정용안(Chung Yong-An) - 가톨릭대학교 의과대학 핵의학교실
양영순(Yang Yung-Soon) - 보훈공단 중앙보훈병원 신경과

Abstract

Background: Clinical diagnosis of multiple system atrophy (MSA) relays on signs and symptoms that are often difficult to identify particularly at early stage. Indeed neuropathological studies have demonstrated that Parkinson variant of MSA (MSA-P) is the first cause of misdiagnosis in a cohort of patients presenting with parkinsonian features. But accurate diagnosis of these disorders is important for deciding on treatment, appropriate advice and prognosis since atypical parkinsonian disorders are characterized by poor response to dopaminergic treatment and more rapid disease progression. Therefore, we conducted this study to investigate difference of perfusion Single Photon Emission Computed Tomography (SPECT) in patients with the early phase of MSA-P using SPM program.

Methods: We recruited consecutively 21 patients with MSA-P and 48 age-matched healthy controls. All subjects underwent Tc-99m HMPAO perfusion SPECT and this perfusion images were analyzed.

Results: For MSA-P, only hypoperfusion was seen in the middle frontal gyrus of left frontal lobe, superior frontal gyrus of right frontal lobe, precentral gyrus of left frontal lobe, middle frontal gyrus of right frontal lobe and precentral gyrus of right frontal lobe with respect to healthy subjects.

Conclusions: We cautiously assume that perfusion SPECT may offer significant advantages compared to other imaging techniques in the assessment of neuronal degeneration in MSA-P and may help the clinician in the diagnostic characterization of patients presenting with atypical parkinsonism.

키워드

multiple system atrophy, Tc-99m HMPAO perfusion SPECT, Frontal lobe

KMID : 1100220140130020037

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건강보험코드

초기 다계통위축증에 대한 뇌관류 Single Photon Emission Computed Tomography의 임상적 유용성 Clinical Usefulness of 99mTc-Hexamethyl Propylene Amine Oxime Perfusion Single Photon Emission Computed Tomography for Early Phase Multiple System Atrophy

Abstract

키워드

초기 다계통위축증에 대한 뇌관류 Single Photon Emission Computed Tomography의 임상적 유용성
Clinical Usefulness of 99mTc-Hexamethyl Propylene Amine Oxime Perfusion Single Photon Emission Computed Tomography for Early Phase Multiple System Atrophy