Eosinophils in Colorectal Neoplasms Associated with Expression of CCL11 and CCL24

Journal of Pathology and Translational Medicine 2016년 50권 1호 p.45 ~ p.51

조혁(Cho Hyuck) - Kyung Hee University College of Medicine Department of Pathology
임성직(Lim Sung-Jig) - Kyung Hee University Hospital at Gangdong Department of Pathology
원규연(Won Kyu-Yeoun) - Kyung Hee University Hospital at Gangdong Department of Pathology
배고은(Bae Go-Eun) - Kyung Hee University Graduate School of Medicine Departments of Pathology
김교영(Kim Gou-Young) - Kyung Hee University Hospital at Gangdong Department of Pathology
민지원(Min Ji-Won) - Kyung Hee University Graduate School of Medicine Departments of Pathology
노병주(Noh Byeong-Joo) - Kyung Hee University School of Medicine Department of Pathology

Abstract

Background: A decrease in the number of tissue eosinophils is known to reflect the malignancy potential of neoplastic lesions and even prognosis. Increased levels of the chemokines CCL11 and CCL24 in serum and tissue are also known to have diagnostic value as serum tumor markers or prognostic factors. The aim of this study was to evaluate the correlation between the degree of tissue eosinophilia and the expression of these chemokines in the glandular and stromal cells of colorectal neoplastic lesions ranging from benign to malignant tumors.


Methods: We counted the number of infiltrating eosinophils in neoplastic lesion tissue and we evaluated the expression of CCL11 and CCL24 in glandular cells and stromal cells by immunohistochemical staining.


Results: The results showed that the number of eosinophils decreased significantly and the expression of CCL11 and CCL24 in glandular cells decreased with tumor progression, whereas the stromal expression of CCL11 and CCL24 appeared to increase.


Conclusions: The discrepancy in CCL11 and CCL24 expression between glandular cells and stromal cells might shed light on how colorectal cancer evades the immune system, which would enable further development of immunotherapies that target these chemokines. Further research on eosinophil biology and the expression pattern of chemokines in tumor cells is needed.

키워드

Eosinophils, CCL11, CCL24, Colorectal neoplasms
원문 및 링크아웃 정보
등재저널 정보
학술진흥재단(KCI) KoreaMed 대한의학회 회원 
주제코드
주제명(Target field)
연구대상(Population)
연구참여(Sample size)
대상성별(Gender)
질병특성(Condition Category)
연구환경(Setting)
연구설계(Study Design)
연구기간(Period)
중재방법(Intervention Type)
중재명칭(Intervention Name)
키워드(Keyword)
유효성결과(Recomendation)
The number of eosinophils decreased significantly and the expression of CCL11 and CCL24 in glandular cells decreased with tumor progression, whereas the stromal expression of CCL11 and CCL24 appeared to increase.
연구비지원(Fund Source)
근거수준평가(Evidence Hierarchy)
출판년도(Year)
참여저자수(Authors)
대표저자
KCD코드
ICD 03
건강보험코드