간암 동물모델의 현황 및 전임상 연구에서의 활용
AnimalAnimal Models of Liver Cancer: Current Status and Application in Preclinical Research

Journal of Liver Cancer 2017년 17권 1호 p.1 ~ p.14

주혜림(Ju Hye-Lim) - 브리티쉬 콜롬비아대학교 의과대학 소화기내과
노원상(Ro Weon-Sang) - 연세대학교 의과대학 소화기내과

Abstract

Hepatocellular carcinoma (HCC) is one of the most common cancers worldwide. HCC develops in various causes ? Viral hepatitis infection, toxins, or other liver conditions - by activation of oncogenes and/or inactivation of tumor suppressors. Understanding of signal pathways and protein-protein interactions critical in tumor development may lead to novel treatment strategy. To evaluate the progression of HCC and effects of potential therapies, various animal models have been established. Experimental models of HCC provide valuable tools to investigate the risk factors, new treatment modalities and biologic characteristics. Subcutaneous xenograft models have been widely used in the past. However, with the advancement of in vivo imaging technology, investigators are more concerned with the orthotopic models nowadays. Genetically engineered mouse models have greatly facilitated studies of gene function in HCC development. Lately, a novel approach for stable gene expression in mouse hepatocytes by hydrodynamic injection has been developed. Each model has its own advantages and disadvantages. Therefore, selecting the optimal models based on study objectives is necessary. In this review, we highlight both the frequently used mouse models and some emerging ones with emphasis on their merits or defects, and give advices for investigators to choose a ‘‘best-fit’’ animal model in HCC research.

키워드

Hepatocellular carcinoma, Liver cancer animal model
원문 및 링크아웃 정보
등재저널 정보
학술진흥재단(KCI) 대한의학회 회원 
주제코드
주제명(Target field)
연구대상(Population)
연구참여(Sample size)
대상성별(Gender)
질병특성(Condition Category)
연구환경(Setting)
연구설계(Study Design)
연구기간(Period)
중재방법(Intervention Type)
중재명칭(Intervention Name)
키워드(Keyword)
유효성결과(Recomendation)
This study described both the frequently used mouse models and some emerging ones with emphasis on their merits or defects, and give advices for investigators to choose a ‘‘best-fit’’ animal model in HCC research.
연구비지원(Fund Source)
근거수준평가(Evidence Hierarchy)
출판년도(Year)
참여저자수(Authors)
대표저자
KCD코드
ICD 03
건강보험코드