Multi-institutional analysis of T3 subtypes and adjuvant radiotherapy effects in resected T3N0 non-small cell lung cancer patients
Radiation Oncology Journal 2015³â 33±Ç 2È£ p.75 ~ p.82
ÃÖÀ±¼±(Choi Yun-Seon) - Inje University College of Medicine Inje University Busan Paik Hospital Department of Radiation Oncology
ÀÌÀÍÀç(Lee Ik-Jae) - Yonsei University College of Medicine Department of Radiation Oncology
ÀÌ⿵(Lee Chang-Young) - Yonsei University College of Medicine Severance Hospital Department of Thoracic and Cardiovascular Surgery
Á¶ÀçÈ£(Cho Jae-Ho) - Yonsei University College of Medicine Department of Radiation Oncology
ÃÖ¿øÈÆ(Choi Won-Hoon) - Yonsei University College of Medicine Department of Radiation Oncology
À±È«ÀÎ(Yoon Hong-In) - Yonsei University College of Medicine Department of Radiation Oncology
ÀÌÀ±ÇÑ(Lee Yun-Han) - Yonsei University College of Medicine Department of Radiation Oncology
ÀÌâ°É(Lee Chang-Geol) - Yonsei University College of Medicine Department of Radiation Oncology
±Ý±ââ(Keum Ki-Chang) - Yonsei University College of Medicine Department of Radiation Oncology
Á¤°æ¿µ(Chung Kyung-Young) - Yonsei University College of Medicine Department of Thoracic and Cardiovascular Surgery
¼®ÁøÇÔ(Seok Jin-Haam) - Yonsei University College of Medicine Severance Hospital Department of Thoracic and Cardiovascular Surgery
¹éȿä(Paik Hyo-Chae) - Yonsei University College of Medicine Department of Thoracic and Cardiovascular Surgery
ÀÌ°±Ô(Lee Kang-Kyoo) - Wonkwang University School of Medicine Department of Radiation Oncology
¹®¼º·Ï(Moon Sun-Rock) - Wonkwang University School of Medicine Department of Radiation Oncology
ÀÌÁ¾¿µ(Lee Jong-Young) - Wonju Severance Christian Hospital Department of Radiation Oncology
¹Ú°æ¶õ(Park Kyung-Ran) - Ewha Womans University Hospital Department of Radiation Oncology
±è¿µ¼®(Kim Young-Suk) - Jeju National University Hospital Department of Radiation Oncology
Abstract
Purpose: We evaluated the prognostic significance of T3 subtypes and the role of adjuvant radiotherapy in patients with resected the American Joint Committee on Cancer stage IIB T3N0M0 non-small cell lung cancer (NSCLC).
Materials and Methods: T3N0 NSCLC patients who underwent resection from January 1990 to October 2009 (n = 102) were enrolled and categorized into 6 subgroups according to the extent of invasion: parietal pleura chest wall invasion, mediastinal pleural invasion, diaphragm invasion, separated tumor nodules in the same lobe, endobronchial tumor <2 cm distal to the carina, and tumor-associated collapse.
Results: The median overall survival (OS) and disease-free survival (DFS) were 55.3 months and 51.2 months, respectively. In postoperative T3N0M0 patients, the tumor size was a significant prognostic factor for survival (OS, p = 0.035 and DFS, p = 0.035, respectively). Patients with endobronchial tumors within 2 cm of the carina also showed better OS and DFS than those in the other T3 subtypes (p = 0.018 and p = 0.016, respectively). However, adjuvant radiotherapy did not cause any improvement in survival (OS, p = 0.518 and DFS, p = 0.463, respectively). Only patients with mediastinal pleural invasion (n = 25) demonstrated improved OS and DFS after adjuvant radiotherapy (n = 18) (p = 0.012 and p = 0.040, respectively).
Conclusion: The T3N0 NSCLC subtype that showed the most favorable prognosis is the one with endobronchial tumors within 2 cm of the carina. Adjuvant radiotherapy is not effective in improving survival outcome in resected T3N0 NSCLC.
Å°¿öµå
Non-small cell lung cancer, Adjuvant radiotherapy, Prognostic factor
KMID :
1038620150330020075
¿ø¹® ¹× ¸µÅ©¾Æ¿ô Á¤º¸
µîÀçÀú³Î Á¤º¸
À¯È¿¼º°á°ú(Recomendation)
Adjuvant radiotherapy did not cause any improvement in survival (OS, p = 0.518 and DFS, p = 0.463, respectively). Patients with mediastinal pleural invasion demonstrated improved OS and DFS after adjuvant radiotherapy (n = 18) (p = 0.012 and p = 0.040, respectively).