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전형적인 알레르기 증상으로 내원한 6세 미만 소아 환자에서 항원 감작 패턴: 단일 기관 연구
Sensitization patterns to common allergens in Korean children younger than 6 years of age presenting with typical symptoms or signs of allergic diseases: a single center study

Allergy Asthma & Respiratory Disease 2014년 2권 4호 p.272 ~ p.276

윤정원(Yoon Jung-Won) - 명지병원 소아청소년과
이상민(Lee Sang-Min) - 명지병원 소아청소년과
김준환(Kim Joon-Hwan) - 차의과학대학교 소아과학교실
김나연(Kim Na-Yeon) - 차의과학대학교 소아과학교실
백지현(Baek Ji-Hyeon) - 차의과학대학교 소아과학교실
백혜성(Baek Hye-Sung) - 한림대학교 의과대학 강동성심병원 소아청소년과
지혜미(Jee Hye-Mi) - 차의과학대학교 소아과학교실
김형윤(Kim Hyung-Yun) - 분당제생병원 소아청소년과
최선희(Choi Sun-Hee) - 경희대학교 의과대학 소아과학교실
김기은(Kim Ki-Eun) - 차의과학대학교 소아과학교실
염혜영(Yum Hye-Yung) - 서울의료원 소아청소년과
한만용(Han Man-Yong) - 차의과학대학교 소아과학교실
김진택(Kim Jin-Tack) - 가톨릭대학교 의과대학 소아과학교실
신윤호(Shin Youn-Ho) - 차의과학대학교 소아과학교실

Abstract

Purpose: Population studies have reported that sensitization to inhalant allergens is rare in young children; however, most subjects in those studies had little or no symptoms or signs highly suggestive of allergic diseases. The aim of the present study was to assess the prevalence of sensitization to inhalant allergens in young children with symptoms and/or signs of allergic disease.

Methods: We analyzed the results of all specific IgE tests performed at our hospital laboratory in children younger than 6 years presenting with symptoms and/or signs highly suggestive of allergic diseases between 2008 and 2013. Specific IgE tests for Dermatophagoides pteronyssinus, Dermatophagoides farinae, Alternaria alternata, German cockroach, cat dander, egg white or egg yolk, milk, peanut, and soybean were performed on 295 children; a specific IgE concentration ≥0.35 or ≥0.2 IU/mL was considered positive. We also compared allergen sensitization rates using the two cutoff values.

Results: One hundred eighty-one children (61.4%) were positive to at least 1 allergen tested and 53 children (18.9%) were positive to at least 1 inhalant allergen when a specific IgE concentration ≥0.35 IU/mL was considered positive. The children were more likely to have asthma or allergic rhinitis when they were sensitized to any inhalant allergen, particularly house dust mites. The prevalence of sensitization to inhalant allergens increased with age (P<0.001). There was no significant difference in the prevalence of polysensitization among different age groups, but sensitization to both inhalant and food allergens significantly increased with age.

Conclusion: Our results suggest that specific IgE tests to common inhalant allergens, particularly the house dust mites, may be considered when performing blood screening tests for young children presenting with symptoms and/or signs of allergic diseases.

키워드

Allergens, Child, Sensitization

KMID : 1035620140020040272

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DOI

KCD코드

ICD 03

건강보험코드

전형적인 알레르기 증상으로 내원한 6세 미만 소아 환자에서 항원 감작 패턴: 단일 기관 연구 Sensitization patterns to common allergens in Korean children younger than 6 years of age presenting with typical symptoms or signs of allergic diseases: a single center study

Abstract

키워드

전형적인 알레르기 증상으로 내원한 6세 미만 소아 환자에서 항원 감작 패턴: 단일 기관 연구
Sensitization patterns to common allergens in Korean children younger than 6 years of age presenting with typical symptoms or signs of allergic diseases: a single center study