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2009 Influenza A H1N1 감염 중 소아 중증 환자에 대한 고용량 Oseltamivir 투여 효과
Effectiveness of double-dose oseltamivir for pediatric patients with severe 2009 pandemic influenza A H1N1

Allergy Asthma & Respiratory Disease 2014년 2권 1호 p.64 ~ p.69

조현석(Cho Hyun-Seok) - 강원대학교 의학전문대학원 소아과학교실
양정희(Yang Jeong-Hee) - 강원대학교 의학전문대학원 가정의학교실
이준호(Lee Joon-Ho) - 강원대학교 의학전문대학원 소아과학교실
안성연(Ahn Sung-Yeon) - 강원대학교 의학전문대학원 소아과학교실
이현수(Lee Hyeon-Soo) - 강원대학교 의학전문대학원 소아과학교실
김자경(Kim Ja-Kyoung) - 강원대학교 의학전문대학원 소아과학교실
민세라(Min Se-Ra) - 강원대학교 의학전문대학원 소아과학교실

Abstract

Purpose: We aimed to evaluate the use and safety of double dose oseltamivir for patients manifesting severe respiratory symptoms or showing no improvement of clinical symptoms after 72 hours’ treatment with the usual oseltamivir dosage.

Methods: We analyzed the clinical features of 2009 influenza A H1N1 inpatients who had been admitted to a university hospital’s Department of Pediatrics between August 2009 and January 2010. The Influenza A H1N1 diagnoses were confirmed by real-time reverse transcriptase polymerase chain reaction.

Results: The study participants numbered 157 (mean age, 5.0 years; male-to-female ratio, 1.1:1). Among them, twenty (mean age, 5.2 years) were administered double dose oseltamivir. This double dose group showed higher peak body temperatures and more abnormal radiologic results than the other, usual-dose group. The mean time duration between high fever and afebrile status after initiation of double-dose oseltamivir administration was 2.1 days, whereas that within the usual-dose group was 1.7 days. There were no adverse effects in the patients treated with double-dose oseltamivir.

Conclusion: Double-dose oseltamivir was well tolerated in patients with severe 2009 influenza A H1N1 infection.

키워드

Influenza A virus, H1N1 subtype, Pediatrics, Severity of illness index, Oseltamivir

KMID : 1035620140020010064

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ICD 03

건강보험코드

2009 Influenza A H1N1 감염 중 소아 중증 환자에 대한 고용량 Oseltamivir 투여 효과 Effectiveness of double-dose oseltamivir for pediatric patients with severe 2009 pandemic influenza A H1N1

Abstract

키워드

2009 Influenza A H1N1 감염 중 소아 중증 환자에 대한 고용량 Oseltamivir 투여 효과
Effectiveness of double-dose oseltamivir for pediatric patients with severe 2009 pandemic influenza A H1N1