Adult-Onset Sellar and Suprasellar Atypical Teratoid Rhabdoid Tumor Treated with a Multimodal Approach: A Case Report
Brain Tumor Research and Treatment 2014³â 2±Ç 2È£ p.108 ~ p.113
(Park Hae-Gi) - Yonsei University College of Medicine Department of Neurosurgery
À±Á¾Çü(Yoon Jong-Hyung) - National Cancer Center Pediatric Oncology Center
±è¼¼ÈÆ(Kim Se-Hoon) - Yonsei University College of Medicine Department of Pathology
Á¶°üÈ£(Cho Kwan-Ho) - National Cancer Center Proton Therapy Center
¹ÚÇöÁø(Park Hyeon-Jin) - National Cancer Center Pediatric Oncology Center
±è¼±È£(Kim Sun-Ho) - Yonsei University College of Medicine Department of Neurosurgery
±èÀÇÇö(Kim Eui-Hyun) - Yonsei University College of Medicine Department of Neurosurgery
Abstract
We report a very rare case of sellar and suprasellar atypical teratoid rhabdoid tumor (ATRT) in a 42-year-old female patient. The tumor was removed subtotally with a transsphenoidal approach. Histopathologic study showed rhabdoid cells with prominent nucleoli and abundant cytoplasm. Immunohistochemistry for INI1 was completely negative in the tumor cells, consistent with ATRT. After surgery, she received radiotherapy including spinal irradiation with proton beam therapy and subsequent chemotherapy, with no evidence of recurrence for more than 2 years. Up to date, this is the 8th case of an adult-onset ATRT in the sellar or suprasellar region. Despite its rarity, ATRTs should be considered in the differential diagnosis of an unclear malignant sellar or suprasellar lesion in adult patients and the treatment strategies for adult ATRT patients could be differentiated from those of pediatric ATRT patients.
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Adult-onset, Atypical teratoid rhabdoid tumor, INI1, Sellar, Suprasellar
KMID :
1035520140020020108
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