Fractionated Gamma Knife Radiosurgery for Benign Perioptic Tumors: Outcomes of 38 Patients in a Single Institute
Brain Tumor Research and Treatment 2014³â 2±Ç 2È£ p.56 ~ p.61
ÁöűÙ(Jee Tae-Keun) - Sungkyunkwan University School of Medicine Samsung Medical Center Department of Neurosurgery
¼³È£ÁØ(Seol Ho-Jun) - Sungkyunkwan University School of Medicine Samsung Medical Center Department of Neurosurgery
ÀÓ¿ë¼®(Im Yong-Seok) - Sungkyunkwan University School of Medicine Samsung Medical Center Department of Neurosurgery
°øµÎ½Ä(Kong Doo-Sik) - Sungkyunkwan University School of Medicine Samsung Medical Center Department of Neurosurgery
³²µµÇö(Nam Do-Hyun) - Sungkyunkwan University School of Medicine Samsung Medical Center Department of Neurosurgery
¹Ú°ü(Park Kwan) - Sungkyunkwan University School of Medicine Samsung Medical Center Department of Neurosurgery
½ÅÇüÁø(Shin Hyung-Jin) - Sungkyunkwan University School of Medicine Samsung Medical Center Department of Neurosurgery
ÀÌÁ¤ÀÏ(Lee Jung-Il) - Sungkyunkwan University School of Medicine Samsung Medical Center Department of Neurosurgery
Abstract
Background: This study was performed to evaluate the efficacy and safety of fractionated Gamma Knife radiosurgery (GKRS) for perioptic lesions.
Methods: Thirty-eight patients with perioptic tumors were treated at our institute from May 2004 to December 2008. All patients had a lesion in close contact with the optic apparatus. Twenty-four of these patients had undergone surgical resection before fractionated GKRS. Radiation was delivered in four sessions with 12 hours intervals between sessions. The mean target volume was 3,851 mm3 and the median cumulative marginal dose was 20 Gy. The median follow-up was 38.2 months. Visual acuity and visual fields were analyzed according to visual impairment score using the German Ophthalmological Society guidelines.
Results: Tumor control was achieved in 35 (94.6%) of the 37 patients with available follow-up images. Progressive tumor growth was observed in two craniopharyngioma patients (5.4%). Favorable visual outcomes in the postoperative period were achieved in 94.7% of cases (36/38). Sixteen patients showed visual function after fractionated GKRS, twenty cases were stationary, and two patients showed visual function deterioration after GKRS.
Conclusion: GKRS is a safe and effective alternative to either surgery or fractionated radiotherapy for selected benign lesions that are adjacent to the optic apparatus.
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Gamma Knife radiosurgery, Fractionated radiosurgery, Stereotactic radiosurgery, Tumor control, Visual outcome
KMID :
1035520140020020056
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