Glioblastoma in a Patient with Neurofibromatosis Type 1: A Case Report and Review of the Literature

Brain Tumor Research and Treatment 2014³â 2±Ç 1È£ p.36 ~ p.38

Á¤Å¼®(Jeong Tae-Seok) - Gachon University Gil Medical Center Department of Neurosurgery
À̱âÅÃ(Yee Gi-Taek) - Gachon University Gil Medical Center Department of Neurosurgery

Abstract

Neurofibromatosis type 1 (NF1) is an autosomal dominantly inherited familial tumor syndrome. Benign tumors such as pilocytic astrocytoma, optic glioma make up the majority of intracranial neoplasms in patients with NF1. There have only been a handful of cases in which adult glioblastoma presented with NF1. A 32-year-old male presented with headache and radiological studies showing a high grade intra-axial tumor. The patient underwent gross total surgical excision and the pathology revealed glioblastoma. After the surgery, he received concomitant chemo-radiotherapy with temozolomide and adjuvant temozolomide chemotherapy. We report a NF1 patient who developed glioblastoma and reviewed related articles.

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Glioblastoma, Neurofibromatosis type 1, CCRT, Temozolomide
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