¹ÚÁÖ¿µ(Park Ju-Young) - National Cancer Center Cancer Cell and Molecular Biology Branch
ÀÌÁ¤Àº(Lee Jeong-Eun) - National Cancer Center Cancer Cell and Molecular Biology Branch
¹ÚÁ¾¹è(Park Jong-Bae) - National Cancer Center Specific Organs Cancer Branch
À¯Çå(Yoo Heon) - National Cancer Center Specific Organs Cancer Branch
À̼ºÈÆ(Lee Seung-Hoon) - National Cancer Center Specific Organs Cancer Branch
±èÁ¾Çå(Kim Jong-Heon) - National Cancer Center Cancer Cell and Molecular Biology Branch
Abstract
More than 98% of eukaryotic tanscriptomes are composed of non-coding RNAs with no functional protein-coding capacity. Those transcripts also include tens of thousands of long non-coding RNAs (lncRNAs) which are emerging as key elements of cellular homeostasis, essentially tumorigenesis steps. However, we are only beginning to understand the nature and extent of the involvement of lncRNAs on tumorigeneis. Here, we highlight recent progresses that have identified a myriad of molecular functions on tumorigenesis for several lncRNAs including metastasis-associated lung adenocarcinoma transcript 1 (MALAT1), prostate cancer associated non-coding RNA 1 (PRNCR1), prostate cancer gene expression marker 1 (PCGEM1), H19, and homeobox transcript antisense intergenic RNA (HOTAIR), and several new lncRNAs for glioma development. Potential therapeutic approaches for the lncRNAs in various human diseases are also discussed.
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Non-coding RNA, lncRNA, Tumorigenesis, Glioma
KMID :
1035520140020010001
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