Polymorphism of XRCC1 Codon 399 and Prognosis of Non-Small Cell Lung Cancer Patients After Radiotherapy

Molecular & Cellular Toxicology 2005년 1권 4호 p.217 ~ p.223

조은경(Cho Eun-Kyung) - 울산대학교 의과대학 방사선종양학교실
윤상민(Yoon Sang-Min) - 울산대학교 의과대학 방사선종양학교실
이관희(Lee Kwan-Hee) - 인하대학교 의과대학 예방의학교실
(Park Heon-Ju) - 인하대학교 의과대학 미생물학교실
김진희(Kim Jin-Hee) - 서울대학교 의과대학 예방의학교실
홍용태(Hong Yong-Tae) - 서울대학교 의과대학 예방의학교실

Abstract

To assess that the XRCC1 399Gln variant contributes to sensitivity to ionizing radiation treatment and is associated with progression-free and overall survival, one hundred and ninety-five lung cancer patients were recruited at the Asan Medical Center from 2000 to 2003. We determined the genotypes of the XRCC1 genes by PCR-RFLP. Kaplan-Meier survival curves and the log-rank test were used to analyze the effects of genotypes on survival. Hazard ratios, adjusted for age, sex, and other potential confounders, were calculated using the Cox-proportional hazard model. Patients carrying the 399Gln variant allele under radiotherapy only had a shorter progression-free and overall survival than those with the 399Arg homozygote. However, when we analyzed for the effect of the XRCC1 Arg399Gln polymorphism in the combined treatment of surgical resection and radiotherapy, we found that patients with the 399Gln variant allele had a longer progression-free and overall survival. This study shows different associations between the XRCC1 Arg399Gln polymorphism and progression-free or overall survival depending on treatment protocol in patients with NSCLC.

키워드

XRCC1, Polymorphism, Lung cancer, Radiotherapy, Prognosis, Survival analysis
원문 및 링크아웃 정보
등재저널 정보
주제코드
주제명(Target field)
연구대상(Population)
연구참여(Sample size)
대상성별(Gender)
질병특성(Condition Category)
연구환경(Setting)
연구설계(Study Design)
연구기간(Period)
중재방법(Intervention Type)
중재명칭(Intervention Name)
키워드(Keyword)
유효성결과(Recomendation)
Patients with the 399Gln variant allele had a longer progression-free and overall survival.
연구비지원(Fund Source)
근거수준평가(Evidence Hierarchy)
출판년도(Year)
참여저자수(Authors)
대표저자
DOI
KCD코드
ICD 03
건강보험코드