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비알코올성 지방간(Non-alcoholic Fatty Lliver Disease) 의 정의, 병인, 자연경과
Definition, Pathogenesis, and Natural Progress of Non-alcoholic Fatty Liver Disease

Journal of Korean Diabetes 2014년 15권 2호 p.65 ~ p.70

전인상(Jeon In-Sang) - 경북대학교 의학전문대학원 내분비대사내과

Abstract

Non-alcoholic fatty liver disease (NAFLD) is emerging as a world-wide health problem and is currently recognized as a hepatic manifestation of metabolic syndrome. It is an umbrella term to describe a wide range of diseases from simple steatosis to non-alcoholic hepatosteatosis (NASH) and NSAH-related liver cirrhosis. NAFLD is mainly associated with insulin resistance which allows increased free fatty acid (FFA) flux to the liver by increasing lipolysis from adipose tissue, triggering macrophage/immune activation, decreasing skeletal muscle glucose uptake, and increasing de novo lipogenesis. Increased FFA pool in the liver, in turn, increases lipotoxic intermediates, such as ceramides, diacylglycerols, and lysophosphatidylcholines, which are responsible for mitochondrial dysfunction and endoplasmic reticulum stress, resulting in inflammation of the liver. When inflammation is severe enough to affect stellate cells, hepatic fibrosis can be induced.

키워드

Free fatty acid, Insulin resistance, Non-alcoholic fatty liver disease, Obesity

KMID : 1030220140150020065

원문 및 링크아웃 정보

등재저널 정보

주제코드

주제명(Target field)

연구대상(Population)

연구참여(Sample size)

대상성별(Gender)

질병특성(Condition Category)

연구환경(Setting)

연구설계(Study Design)

연구기간(Period)

중재방법(Intervention Type)

중재명칭(Intervention Name)

키워드(Keyword)

유효성결과(Recomendation)

연구비지원(Fund Source)

근거수준평가(Evidence Hierarchy)

출판년도(Year)

참여저자수(Authors)

대표저자

DOI

KCD코드

ICD 03

건강보험코드

비알코올성 지방간(Non-alcoholic Fatty Lliver Disease) 의 정의, 병인, 자연경과 Definition, Pathogenesis, and Natural Progress of Non-alcoholic Fatty Liver Disease

Abstract

키워드

비알코올성 지방간(Non-alcoholic Fatty Lliver Disease) 의 정의, 병인, 자연경과
Definition, Pathogenesis, and Natural Progress of Non-alcoholic Fatty Liver Disease