Never-Smoker Lung Cancer Is Increasing

Journal of Lung Cancer 2012³â 11±Ç 2È£ p.89 ~ p.93

°­Çö¿í(Kang Hyun-Wook) - Chonnam National University Hwasun Hospital Lung and Esophageal Cancer Clinic
¹ÚÂù¿ì(Park Chan-Woo) - Chonnam National University Hwasun Hospital Lung and Esophageal Cancer Clinic
±è¿ìÁø(Kim Woo-Jin) - Chonnam National University Hwasun Hospital Lung and Esophageal Cancer Clinic
¼Û»óÀ±(Song Sang-Yun) - Chonnam National University Hwasun Hospital Lung and Esophageal Cancer Clinic
³ª±¹ÁÖ(Na Kook-Joo) - Chonnam National University Hwasun Hospital Lung and Esophageal Cancer Clinic
Á¤Àç¿í(Jeong Jae-Uk) - Chonnam National University Hwasun Hospital Lung and Esophageal Cancer Clinic
À±¹Ì¼±(Yoon Mee-Sun) - Chonnam National University Hwasun Hospital Lung and Esophageal Cancer Clinic
¾È¼ºÀÚ(Ahn Sung-Ja) - Chonnam National University Hwasun Hospital Lung and Esophageal Cancer Clinic
ÃÖÀ¯´ö(Choi Yoo-Duk) - Chonnam National University Hwasun Hospital Lung and Esophageal Cancer Clinic
(Choi Chan) - Chonnam National University Hwasun Hospital Lung and Esophageal Cancer Clinic
ÀÌ´Ù¿î(Lee Da-Un) - Chonnam National University Hwasun Hospital Lung and Esophageal Cancer Clinic
¼±ÇöÁÖ(Seon Hyun-Ju) - Chonnam National University Hwasun Hospital Lung and Esophageal Cancer Clinic
±èÀ±Çö(Kim Yun-Hyeon) - Chonnam National University Hwasun Hospital Lung and Esophageal Cancer Clinic
±Ç¼º¿µ(Kwon Seong-Young) - Chonnam National University Hwasun Hospital Lung and Esophageal Cancer Clinic
¹üÈñ½Â(Bom Hee-Seung) - Chonnam National University Hwasun Hospital Lung and Esophageal Cancer Clinic
¿ÀÀÎÀç(Oh In-Jae) - Chonnam National University Hwasun Hospital Lung and Esophageal Cancer Clinic
±è±Ô½Ä(Kim Kyu-Sik) - Chonnam National University Hwasun Hospital Lung and Esophageal Cancer Clinic
±è¿µÃ¶(Kim Young-Chul) - Chonnam National University Hwasun Hospital Lung and Esophageal Cancer Clinic

Abstract

Purpose: Lung cancer has been the leading cause of death in South Korea since the year 2000. Adenocarcinoma became the most frequent type in the national survey of lung cancer since year 2005.

Materials and Methods: We analyzed 5,456 cases with lung cancer from 2004 to 2012 in a community cancer center. The mean age was 69.9 years, and 78.9% was male.

Results: Adenocarcinoma (ADC, 40.8%) was the most frequent type, followed by squamous cell carcinoma (SQC, 36.4%), small cell carcinoma (SCC, 14.8%) and non-small cell lung cancer (NSCLC) not otherwise specified (8.1%). In male patients, SQC was the most frequent type (43.5%), while ADC showed highest incidence in females (72.6%). Anatomic stage at diagnosis in NSCLC was I (10.3%), II (5.8%), IIIA (15.7%), IIIB (19.2%), and IV (49.0%). In SCC, 41.7% was in limited stage and 58.3% was diagnosed in extensive stage. The proportion of never smoker has been increased from 19.1% in 2004¡­2008 to 25.4% in 2009¡­2012. Never-smokers are more likely to be female (68.2% vs. 4.0%, p<0.001), have ADC (69.9% vs. 31.3%, p<0.001), and manifest as stage IV disease (58.5% vs. 45.2%, p<0.001), compared to smokers. Among 1,908 cases whose initial treatment was recorded, 42.5% received chemotherapy, 25.7% received radiation treatment, 20.5% received surgery and the remaining 11.3% received supportive cares only or transferred to other health care facilities.

Conclusion: In conclusion, proportion of lung cancer in never-smoker is increasing. As screening for smokers will miss this growing population, we need to discover biomarkers to find high risk population of lung cancer.

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Lung neoplasms, Epidemiology, Smoking, Female
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The proportion of never smoker has been increased from 19.1% in 2004¡­2008 to 25.4% in 2009¡­2012. Never-smokers are more likely to be female have Adenocarcinoma. Among 1,908 cases whose initial treatment was recorded, 42.5% received chemotherapy, 25.7% received radiation treatment, 20.5% received surgery and the remaining 11.3% received supportive cares only or transferred to other health care facilities.
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