Fractionated Stereotactic Radiotherapy for Metastatic Brain Tumor in Non-Small Cell Lung Cancer

Journal of Lung Cancer 2002년 1권 1호 p.48 ~ p.54

조문준(Cho Moon-June) - 충남대학교 의과대학 치료방사선과교실
김기환(Kim Ki-Hwan) - 충남대학교 의과대학 치료방사선과교실
김준상(Kim Jun-Sang) - 충남대학교 의과대학 방사선 종양학과교실
김선환(Kim Seon-Hwan) - 충남대학교 의과대학 신경외과학교실
송시헌(Song Shi-Hun) - 충남대학교 의과대학 신경외과학교실
송창준(Song Chang-Jun) - 충남대학교 의과대학 진단방사선과학교실
임승평(Lim Seung-Pyung) - 충남대학교 의과대학 내과학교실
김선영(Kim Sun-Young) - 충남대학교 의과대학 내과학교실
김재성(Kim Jae-Sung) - 충남대학교 의과대학 치료방사선과교실

Abstract

Purpose: To evaluate the results of treatment with fractionated stereotactic radiotherapy for metastatic brain tumors in non-small cell lung cancer.

Materials and Methods: Between August 1997 and August 2001, 17 patients, with metastatic brain tumors in non-small cell lung cancer (26 lesions), completed frameless fractionated stereotactic radiotherapy. All patients received a 30∼36 Gy/10∼20 fx external beam irradiation to the whole brain. Twelve received fractionated stereotactic radiotherapy for a single lesion, 3 for 2 lesions and 1 each for 3 and 5 lesions. The median tumor volume was 1.7 cc (0.3∼55.2 cc). The fractionation schedule for the fractionated stereotactic radiotherapy was 21 Gy/3 fx in 8 lesions, 25 Gy/5 fx in 7, 18 Gy/1 fx in 6, 30 Gy/5 fx in 4 and 15 Gy/5 fx in 1. Multiple-arc, and 3D conformal, fractionated stereotactic radiotherapy, were delivered to 24 and 2 lesions, respectively. Follow-up was possible in all patients.

Results: Nine out of 13 patients with follow-up radiological evaluations achieved a complete response (CR). The overall median survival, and 1 and 2 year survival rates were 20 months, and 64 and 28%, respectively. The median survival, and the 1 and 2 year survival rate of CR group were 20 months, and 73 and 22%, respectively. No patient has experienced any acute side reactions or late complications from the fractionated stereotactic radiotherapy.

Conclusion: Although the number of patients treated with fractionated stereotactic radiotherapy was small, and follow-up period short, this study suggests that external beam irradiation to the whole brain, with 30 Gy/10 fx followed by fractionated stereotactic radiotherapy, could be a good treatment option for patients with metastatic brain tumors in non-small cell lung cancer.

키워드

Metastatic brain tumor, Fractionated stereotactic radiotherapy, NSCLC
원문 및 링크아웃 정보
등재저널 정보
주제코드
주제명(Target field)
연구대상(Population)
연구참여(Sample size)
대상성별(Gender)
질병특성(Condition Category)
연구환경(Setting)
연구설계(Study Design)
연구기간(Period)
중재방법(Intervention Type)
중재명칭(Intervention Name)
키워드(Keyword)
유효성결과(Recomendation)
Nine out of 13 patients with follow-up radiological evaluations achieved a complete response (CR). The overall median survival, and 1 and 2 year survival rates were 20 months, and 64 and 28%, respectively.
연구비지원(Fund Source)
근거수준평가(Evidence Hierarchy)
출판년도(Year)
참여저자수(Authors)
대표저자
DOI
KCD코드
ICD 03
건강보험코드