A Rare Case of Gastric Carcinosarcoma with Neuroendocrine Differenti

The Korean Journal of Helicobacter and Upper Gastrointestinal Research 2014³â 14±Ç 2È£ p.121 ~ p.125

½ÅÇØÁø(Shin Hae-Jin) - Chungnam National University Hospital Department of Internal Medicine
ÁÖÁ¾¼®(Ju Jong-Seok) - Chungnam National University Hospital Department of Internal Medicine
¹®Èñ¼®(Moon Hee-Seok) - Chungnam National University Hospital Department of Internal Medicine
°­¼±Çü(Kang Sun-Hyung) - Chungnam National University Hospital Department of Internal Medicine
¼ºÀç±Ô(Sung Jae-Kyu) - Chungnam National University Hospital Department of Internal Medicine
Á¤Çö¿ë(Jeong Hyun-Yong) - Chungnam National University Hospital Department of Internal Medicine
¼Û±Ô»ó(Song Kyu-Sang) - Chungnam National University Hospital Department of Internal Medicine

Abstract

Carcinosarcoma of the stomach is a rare biphasic tumor that consists of both carcinomatous and sarcomatous components. In the gastrointestinal tract, carcinosarcoma is most frequently seen in the esophagus and rarely in the stomach. Tubular or papillary ad-enocarcinomas are common carcinomatous components, whereas mesenchymal sarcomatous components may vary. Neuroendo-crine carcinomatous differentiation in carcinomatous components is extremely rare. We report a 62-year-old female patient with a history of dyspepsia for one-month-history. Endoscopic findings showed a ulcerofungating lesion, which infiltrated from the poste-rior wall of the antrum to the posterior wall of the gastric angle. Radical subtotal gastrectomy was performed. In the resected speci-men, immunohistochemical studies showed two positive reactions for epithelial and mesenchymal markers. Based on the above findings, the patient was diagnosed with a gastric carcinosarcoma with neuroendocrine differentiation.

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Carcinosarcoma, Stomach, Neuroendocrine differentiation factor, human, Immunohistochemistry
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