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Pharmacological Therapy of Peptic Ulcer

The Korean Journal of Helicobacter and Upper Gastrointestinal Research 2014³â 14±Ç 1È£ p.13 ~ p.17

¿ÀÁ¤È¯(Oh Jung-Hwan) - °¡Å縯´ëÇб³ Àǰú´ëÇÐ ¼º¹Ù¿À·Îº´¿ø ³»°úÇб³½Ç

Abstract

Peptic ulcer disease is one of the most commonly encountered diseases. Despite the decrease of Helicobacter pylori infection, the use of aspirin and non-steroidal anti-inflammatory drugs has increased in recent years. Peptic ulcer bleeding is a common emergency associated with high mortality. As an adjunct to endoscopic treatment, acid suppression with proton pump inhibitors (PPIs) is im-portant in the management of peptic ulcer bleeding. A high dose intravenous PPI is effective in reducing rebleeding and the need for surgery. However, data about non-high dose intravenous PPIs are limited. In addition, novel PPIs are focused in this review, since progress has been made regarding new PPIs.

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Peptic ulcer, Peptic ulcer hemorrhage, Proton pump inhibitors, Therapy
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