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Concurrence of Membranous Glomerulonephritis and Pulmonary Alveolar Proteinosis
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¹ÚºÀ¼ö(Park Bong-Soo) - ÀÎÁ¦´ëÇб³ ÀÇ°ú´ëÇÐ ÇØ¿î´ë¹éº´¿ø ³»°úÇб³½Ç
±è¾ç¿í(Kim Yang-Wook) - ÀÎÁ¦´ëÇб³ ÀÇ°ú´ëÇÐ ÇØ¿î´ë¹éº´¿ø ³»°úÇб³½Ç
±èÇö±¹(Kim Hyun-Kuk) - ÀÎÁ¦´ëÇб³ ÀÇ°ú´ëÇÐ ÇØ¿î´ë¹éº´¿ø ³»°úÇб³½Ç
³ëÅÂÈÆ(No Tae-Hoon) - ÀÎÁ¦´ëÇб³ ÀÇ°ú´ëÇÐ ÇØ¿î´ë¹éº´¿ø ³»°úÇб³½Ç
¼¹Î±³(Seo Min-Gyo) - ÀÎÁ¦´ëÇб³ ÀÇ°ú´ëÇÐ ÇØ¿î´ë¹éº´¿ø ³»°úÇб³½Ç
±è¿¬¹Ì(Kim Yeon-Mee) - ÀÎÁ¦´ëÇб³ ÀÇ°ú´ëÇÐ ÇØ¿î´ë¹éº´¿ø º´¸®°ú
Áø±Ôº¹(Jin Kyu-Bok) - ÀÎÁ¦´ëÇб³ ÀÇ°ú´ëÇÐ ÇØ¿î´ë¹éº´¿ø ³»°úÇб³½Ç
Abstract
Membranous glomerulonephritis is one of the most common causes of nephrotic syndrome in adults. Pulmonary alveolar proteinosis (PAP) is a rare lung disease in which abnormal accumulation of surfactant occurs within the alveoli. We describe a 61-year-old man with concurrent membranous glomerulonephritis and PAP, which is very rare; both are pathophysiologically related to an abnormal immune response. A patient came to hospital with leg edema but no respiratory symptoms. Chest X-ray and CT showed classical PAP findings, which are ground-glass opacities with interlobular septal thickening, in both lung fields. A bubbly whitish secretion retrieved via broncho-alveolar lavage showed neutrophils and lymphocytes as well as Periodic acid-Schiff-positive proteinaceous materials. A kidney biopsy revealed findings of membranous glomerulonephritis with irregular subepithelial deposits by electron microscopy. At 1 year after diagnosis, the membranous glomerulonephritis was well under control with steroids and mycophenolate mofetil but PAP became aggravated gradually and whole-lung lavage was needed.
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Glomerulonephritis, membranous, Pulmonary alveolar proteinosis
KMID :
0882420140870020215
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