ÀüÀ̼º ½Å¼¼Æ÷¾Ï¿¡¼ Everolimus »ç¿ë ÈÄ À¯¹ßµÈ ´ç´¢º´¼º ÄÉÅæ»êÁõ 1¿¹
Case Report of Everolimus-Associated DKA in a Patient with Metastatic Renal Cell Carcinoma
´ëÇѳ»°úÇÐȸÁö 2014³â 86±Ç 6È£ p.761 ~ p.765
±èÀÌ°æ(Kim Lee-Kyung) - ¼¿ï´ëÇб³ ÀÇ°ú´ëÇÐ ³»°úÇб³½Ç
¾Èâȣ(Ahn Chang-Ho) - ¼¿ï´ëÇб³ ÀÇ°ú´ëÇÐ ³»°úÇб³½Ç
ÀÌÁöÀº(Lee Jie-Eim) - ¼¿ï´ëÇб³ ÀÇ°ú´ëÇÐ ³»°úÇб³½Ç
Á¤ÂùÇö(Jung Chan-Hyeon) - ¼¿ï´ëÇб³ ÀÇ°ú´ëÇÐ ³»°úÇб³½Ç
±¸º¸°æ(Koo Bo-Kyeong) - ¼¿ï´ëÇб³ ÀÇ°ú´ëÇÐ ³»°úÇб³½Ç
¹®¹Î°æ(Moon Min-Kyong) - ¼¿ï´ëÇб³ ÀÇ°ú´ëÇÐ ³»°úÇб³½Ç
Abstract
Everolimus, an inhibitor of the mammalian target of the rapamycin (mTOR) pathway, is widely used as an immunosuppressant for the prevention of organ rejection following transplant and to treat metastatic clear-cell type renal cell carcinoma (RCC), breast cancer, and pancreatic neuroendocrine tumors. Everolimus commonly induces metabolic abnormalities such as hyperglycemia, hypercholesterolemia, and hypertriglyceridemia due to concomitant increases in blood glucose levels via the induction of insulin resistance and a decrease in ¥â cell function, which both lead to insulin deficiency. Although abnormal blood glucose levels are observed in more than 50% of patients treated with Everolimus, hyperglycemia exceeding 500 mg/dL is not common and there have been no reports of Everolimus-induced acute hyperglycemic crisis conditions. Here, a novel case of Everolimus-associated diabetic ketoacidosis (DKA) in a patient with RCC is reported.
Å°¿öµå
Everolimus, DKA, Hyperglycemia, Insulin resistance, Metastatic renal cell carcinoma
KMID :
0882420140860060761
¿ø¹® ¹× ¸µÅ©¾Æ¿ô Á¤º¸
µîÀçÀú³Î Á¤º¸
À¯È¿¼º°á°ú(Recomendation)