KCTBASE

약물유해사례 자발보고자료를 통한 국내 중증피부유해반응 원인 약물 분석
Analysis of Drugs Causing Severe Cutaneous Adverse Reactions, Based on the Korean Database of Spontaneously Reported Adverse Drug Reactions

대한내과학회지 2014년 86권 6호 p.710 ~ p.721

김미영(Kim Mi-Yeong) - 서울대학교 의학연구원 알레르기 및 임상면역연구소
양민석(Yang Min-Suk) - 서울대학교 의학연구원 알레르기 및 임상면역연구소
강혜련(Kang Hye-Ryun) - 서울대학교 의학연구원 알레르기 및 임상면역연구소
조상헌(Cho Sang-Heon) - 서울대학교 의학연구원 알레르기 및 임상면역연구소
민경업(Min Kyung-Up) - 서울대학교 의학연구원 알레르기 및 임상면역연구소

Abstract

Background/Aims: Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), and drug reaction with eosinophilia and systemic symptoms (DRESS) are severe cutaneous adverse reactions (SCARs) that also affect the internal organs with high mortality. However, there has been no previous nationwide study of SCARs in Korea.

Method: Cases of SCARs were recruited from the nationwide Korean Pharmacovigilance Research Network database, collected from June 2009 to December 2010, by a spontaneous reporting system. We analyzed age, gender, route of administration and the causative agents. We also reviewed previously published cases of SCARs in Korea.

Results: In total, 100 cases of SJS (66 cases), TEN (7 cases), and DRESS (27 cases) were reported. The mean age of the patients was 54.1 ± 19.8 years and the proportion of males to females was 1:0.88. In total, 81 drugs were reported as causative agents: SJS (61 drugs), TEN (15 drugs), and DRESS (29 drugs). The most commonly reported causative drug was allopurinol (12 cases). Allopurinol (8 cases) and levofloxacin (2 cases) were the most commonly reported causative drugs for SJS and TEN, respectively. In DRESS, allopurinol (4 cases) and vancomycin (4 cases) were the two most common causative drugs. Anti-infective drugs were the most common drug category (75 cases). Carbamazepine was the most commonly reported causative drug according to published cases in Korea.

Conclusions: Allopurinol in the spontaneous reporting system and carbamazepine in the published cases were the most common single causative drugs in SCARs in Korea. Anti-infectives were the most common drug category in the spontaneous reporting system.

키워드

Stevens-Johnson syndrome, Pharmacovigilance, Drug hypersensitivity, Eosinophilia

KMID : 0882420140860060710

원문 및 링크아웃 정보

학회

등재저널 정보

주제코드

주제명(Target field)

연구대상(Population)

연구참여(Sample size)

대상성별(Gender)

질병특성(Condition Category)

연구환경(Setting)

연구설계(Study Design)

연구기간(Period)

중재방법(Intervention Type)

중재명칭(Intervention Name)

키워드(Keyword)

유효성결과(Recomendation)

연구비지원(Fund Source)

근거수준평가(Evidence Hierarchy)

출판년도(Year)

참여저자수(Authors)

대표저자

DOI

KCD코드

ICD 03

건강보험코드

약물유해사례 자발보고자료를 통한 국내 중증피부유해반응 원인 약물 분석 Analysis of Drugs Causing Severe Cutaneous Adverse Reactions, Based on the Korean Database of Spontaneously Reported Adverse Drug Reactions

Abstract

키워드

약물유해사례 자발보고자료를 통한 국내 중증피부유해반응 원인 약물 분석
Analysis of Drugs Causing Severe Cutaneous Adverse Reactions, Based on the Korean Database of Spontaneously Reported Adverse Drug Reactions