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A Case of Different Organ Responses to Immunosuppressive Therapy In a Microscopic Polyangiitis Patient with Interstitial Lung Disease
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ÀÌÀçÁØ(Lee Jae-Joon) - À»Áö´ëÇб³º´¿ø ³»°ú
½ÅÁ¾È£(Shin Jong-Ho) - À»Áö´ëÇб³º´¿ø ³»°ú
¹æ±âÅÂ(Bang Ki-Tae) - À»Áö´ëÇб³º´¿ø ³»°ú
ÃÖÁö¿í(Choi Ji-Wook) - À»Áö´ëÇб³º´¿ø ³»°ú
¹®ÇöÁø(Moon Hyun-Jin) - À»Áö´ëÇб³º´¿ø ³»°ú
ÀüÀç¿õ(Jeon Jae-Woong) - À»Áö´ëÇб³º´¿ø ³»°ú
Á¤Áø¿í(Jeong Jin-Uk) - À»Áö´ëÇб³º´¿ø ³»°ú
Abstract
Microscopic polyangiitis (MPA) is an idiopathic autoimmune disease characterized by systemic vasculitis associated with antineutrophil cytoplasmic autoantibodies. Interstitial lung disease is a less recognized manifestation of MPA and has a poor prognosis. A 61-year-old man presented with persistent cough, sputum and dyspnea. Laboratory examination revealed microscopic hematuria and renal insufficiency. Perinuclear anti-neutrophil cytoplasmic autoantibodies were positive according to serological testing. Computed tomography scans showed bibasilar reticulation and honeycombing in a peripheral distribution. Therefore, renal biopsy was performed, and MPA was diagnosed. After treating with corticosteroids and immunosuppressive agents, the patient had a complete renal response but progressive interstitial lung disease. We report a case of MPA presenting with interstitial lung disease in which the patient experienced different responses in each organ.
Å°¿öµå
Microscopic polyangiitis, Interstitial lung disease, Anti-neutrophil cytoplasmic antibody-associated vasculitis
KMID :
0882420140860010084
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