Predicting the Size of Benign Thyroid Nodules and Analysis of Associated Factors That Affect Nodule Size

Chonnam Medical Journal 2015년 51권 2호 p.97 ~ p.101

서석호(Seo Seok-Ho) - Kwangju Christian Hospital Department of Internal Medicine
김태현(Kim Tae-Hyun) - Kwangju Christian Hospital Department of Internal Medicine
김순호(Kim Soon-Ho) - Kwangju Christian Hospital Department of Internal Medicine
이승현(Lee Seung-Hyun) - Kwangju Christian Hospital Department of Internal Medicine
김종택(Kim Jong-Taek) - Kwangju Christian Hospital Department of Internal Medicine
박대원(Park Dae-Won) - Kwangju Christian Hospital Department of Internal Medicine
이동철(Lee Dong-Chul) - Kwangju Christian Hospital Department of Internal Medicine

Abstract

This study aimed to identify factors that affect the size of benign thyroid nodules and to predict nodule size by using a newly developed model. Because most thyroid nodules are benign, they are commonly only monitored. Only a few studies have evaluated the natural progression or regression of benign thyroid nodules. Large-scale studies on the subject are nonexistent. Between January 2001 and December 2011, our study subjects were selected from among 1,564 patients with benign thyroid nodules (2,469 nodules) in a retrospective analysis. We measured nodule size and volume and attempted to predict nodule size by using a newly developed model. Nodules were considered to have increased in size if the total volume increased by >15%. Nodules that increased in size over time required a longer follow-up period than nodules that decreased in size. The proportion of females and the cystic proportion of the nodules were relatively high in our study sample. For thyroid nodules that increased in size, we analyzed potential predictive factors. Larger nodule volume, extended follow-up period, and high cystic proportion were positively associated with increased nodule size. According to the model we developed in our study, the nodules in the group with an increase in size grew at an approximate rate of 0.034 cm3 per year when controlled for other factors. Percutaneous ethanol injection or radiofrequency ablation is performed for cosmetic purposes and proper functioning if or when nodules reach a certain size. The model used in our study may offer helpful insight in determining an optimal treatment schedule for benign thyroid nodules.

키워드

Thyroid nodule, Ablation techniques, Thyroid gland
원문 및 링크아웃 정보
등재저널 정보
학술진흥재단(KCI) KoreaMed 
주제코드
주제명(Target field)
연구대상(Population)
연구참여(Sample size)
대상성별(Gender)
질병특성(Condition Category)
연구환경(Setting)
연구설계(Study Design)
연구기간(Period)
중재방법(Intervention Type)
중재명칭(Intervention Name)
키워드(Keyword)
유효성결과(Recomendation)
The final volume was positively correlated with a larger initial volume, higher cystic proportion, and longer followup period.
연구비지원(Fund Source)
근거수준평가(Evidence Hierarchy)
출판년도(Year)
참여저자수(Authors)
대표저자
KCD코드
ICD 03
건강보험코드