알코올 사용 장애 환자에서 동반되는 베르니케 뇌병증의 선별검사로서티아민 혈중농도의 진단적 유용성
Diagnostic Usefulness of Blood Thiamine Levels as Screening Tests for Wernicke's Encephalopathy in Patients with Alcohol Use Disorder

중독정신의학 2017년 21권 1호 p.17 ~ p.21

최동렬(Choi Dong-Ryeol) - 연세대학교 의과대학 정신건강의학교실
정영철(Jung Young-Chul) - 연세대학교 의과대학 정신건강의학교실

Abstract

Objectives : The purpose of this study was to evaluate the utility in measuring the blood thiamine and thiamine pyrophosphate (TPP) levels as screening tests for Wernicke encephalopathy in patients with alcohol use disorder.

Methods : We analyzed the demographic, clinical and laboratory data from 35 patients with alcohol use disorder. The blood thiamine and TPP levels were acquired at admission prior to initiation of thiamine intravenous (IV) therapy. We examined whether the blood thiamine and TPP levels correlated with clinical symptoms by applying the Caine's criteria. Patients who met at least one of Caine's criteria were considered at high risk for Wernicke encephalopathy and were treated with high-dose thiamine IV therapy.

Results : There was no correlation between blood thiamine/TPP levels and clinical symptoms of Wernicke encephalopathy. Clinical manifestations of the below-normal TPP-level group were not different from the normal TPP-level group, except that the normal TPP-level group showed a higher revised clinical institute withdrawal assessment for alcohol (CIWA) scores.

Conclusion : Measuring blood thiamine/TPP levels was not sensitive as screening tests for Wernicke encephalopathy among patients with alcohol use disorder. High-dose thiamine IV therapy improved the clinical symptoms of Wernicke encephalopathy in patients with alcohol use disorder.

키워드

베르니케 뇌병증, 티아민, 티아민 피로인산염 농도, 케인의 기준
Wernicke encephalopathy, Thiamine, Thiamine pyrophosphate level, Caine's criteria
원문 및 링크아웃 정보
등재저널 정보
학술진흥재단(KCI) 
주제코드
주제명(Target field)
연구대상(Population)
연구참여(Sample size)
대상성별(Gender)
질병특성(Condition Category)
연구환경(Setting)
연구설계(Study Design)
연구기간(Period)
중재방법(Intervention Type)
중재명칭(Intervention Name)
키워드(Keyword)
유효성결과(Recomendation)
Measuring blood thiamine/TPP levels was not sensitive as screening tests for Wernicke encephalopathy among patients with alcohol use disorder.
연구비지원(Fund Source)
근거수준평가(Evidence Hierarchy)
출판년도(Year)
참여저자수(Authors)
대표저자
DOI
KCD코드
ICD 03
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