AFP-producing acinar cell carcinoma treated by pancreaticoduodenectomy in a patient with a previous radical subtotal gastrectomy by gastric cancer
Çѱ¹°£´ãÃé¿Ü°úÇÐȸÁö 2014³â 18±Ç 1È£ p.33 ~ p.37
±èÀ念(Kim Chang-Young) - Yonsei University College of Medicine Department of Surgery
À̼ºÈ¯(Lee Sung-Hwan) - Yonsei University College of Medicine Department of Surgery
°Ã¢¹«(Kang Chang-Moo) - Yonsei University College of Medicine Department of Surgery
ÀÌ¿ìÁ¤(Lee Woo-Jung) - Yonsei University College of Medicine Department of Surgery
ÀüÇý¹Î(Jeon Hyae-Min) - Yonsei University College of Medicine Department of Pathology
±èÇö±â(Kim Hyun-Ki) - Yonsei University College of Medicine Department of Pathology
Abstract
We report a case of alpha-fetoprotein (AFP)-producing acinar cell carcinoma (ACC) of the pancreas. The tumor was diagnosed in a 72 yearold female after radical subtotal gastrectomy (Billroth I) due to early gastric cancer six months before. The initial serum AFP levels were increased to 2,254.1 IU/ml and preoperative imaging studies showed a mass with approximately 2.5 cm in diameter near the neck of the pancreas. A pancreaticoduodenectomy was performed. The pathologic examination revealed an ill-defined lobulating tumor confined to the pancreas (T1 stage). Immunohisto-chemical study showed that the tumor cells expressed AFP. The Adenosine triphosphate-based chemotherapy re-sponse assay (ATP-CRA) suggested that cisplatin would be more desirable than gemcitabine in AFP-producing ACC of the pancreas as an adjuvant chemotherapy. However, the adjuvant chemotherapy was not performed due to the early pathological stage. The patient died from carcinomatosis and pneumonia. Even if the tumor was on a relatively early stage, an adjuvant treatment should be considered ACC.
Å°¿öµå
Alpha-fetoprotein, Acinar cell carcinoma, Pancreatectomy, Gastric cancer
KMID :
0870420140180010033
¿ø¹® ¹× ¸µÅ©¾Æ¿ô Á¤º¸
µîÀçÀú³Î Á¤º¸
À¯È¿¼º°á°ú(Recomendation)