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항혈소판약물과 생약제의 상호작용: 리뷰
A Review of Herbal Interactions with Antiplatelet Drugs

병원약사회지 2014년 31권 2호 p.691 ~ p.704

천부순(Chun Pu-Soon) - 인제대학교 약학대학
김종윤(Kim Jong-Yoon) - 서울대학교병원 약제부
김정태(Kim Jung-Tae) - 경희대학교 약학대학 강동경희대학교병원 약제부
유기연(Rhew Ki-Yon) - 동덕여자대학교 약학대학

Abstract

Objectives : Antiplatelet agents are commonly used worldwide for the prevention of cardiovascular or cerebrovascular diseases by inhibiting platelet aggregation and thrombus formation. As the herbal medicine and crude drug market is gradually expanding with increased popularity, drug-herb interaction has become a rising topic. The most frequently interacting drugs with herbs were reported to be antiplatelet agents and anticoagulants. The purpose of this
research is to focus on the interactions in antiplatelet agents with herbal medicines in order to present safe use of these agents, including aspirin or clopidogrel, along with the effective use of CAM (Complementary and Alternative Medicine).

Methods : This research includes literatures on only the clinical results of drug interactions, primarily assembled from PubMed and additionally from MedlinePlus Drugs and Supplements Directory, Martindale, Natural Standard, BNF, Stockely’s Herbal Medicines, etc.

Results : Herbs that resulted in teractions with an antiplatelet agent were as follows : aloe vera, garlic, ginger, ginkgo, ginseng, and St. John’s wort. The results were all clinical and had more than one case. Studies on garlic, ginger, and ginkgo were conducted on healthy adult subjects whereas the clinical study on St. John’s wort was conducted on patients with stent placed on their coronary artery.

Conclusions : Although clinical studies and cases on drug-herb interaction had varied results, the results could lead to the conclusion that many herbal medicines will have interactions with antiplatelet agents. Therefore, potential interactions should be considered when simultaneously using herbal medicine and conventional medicine prior to treatment. Further research using a larger population is required for more accurate results.

키워드

Drug-herb interaction, Antiplatelet agent, Herbal medicine

KMID : 0869620140310020691

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주제코드

주제명(Target field)

연구대상(Population)

연구참여(Sample size)

대상성별(Gender)

질병특성(Condition Category)

연구환경(Setting)

연구설계(Study Design)

연구기간(Period)

중재방법(Intervention Type)

중재명칭(Intervention Name)

키워드(Keyword)

유효성결과(Recomendation)

연구비지원(Fund Source)

근거수준평가(Evidence Hierarchy)

출판년도(Year)

참여저자수(Authors)

대표저자

DOI

KCD코드

ICD 03

건강보험코드

항혈소판약물과 생약제의 상호작용: 리뷰 A Review of Herbal Interactions with Antiplatelet Drugs

Abstract

키워드

항혈소판약물과 생약제의 상호작용: 리뷰
A Review of Herbal Interactions with Antiplatelet Drugs