우울증이 치매조기검진에서 간이정신상태검사의 선별검사예측 정확도에 미치는 영향
Influence of Depression on the Prediction Accuracy of Mini-Mental State Examination as Screening Test for Early Detection of Dementia

노인정신의학 2016년 20권 2호 p.108 ~ p.113

김세범(Kim Se-Beom) - 단국대학교 의과대학 정신과학교실
이정재(Lee Jung-Jae) - 단국대학교 의과대학 정신과학교실
이석범(Lee Seok-Bum) - 단국대학교 의과대학 정신과학교실
이경규(Lee Kyung-Kyu) - 단국대학교 의과대학 정신과학교실
백기청(Paik Ki-Chung) - 단국대학교 의과대학 정신과학교실

Abstract

Objective:Depression and cognitive impairment are closely associated in old age. In this study, we investigate the influence of depression on the prediction accuracy of Mini-Mental State Examination (MMSE) as screening test for early detection of dementia.

Methods:Three hundred and twenty one dementia patients and five hundred and thirty five normal control subjects were enrolled in this study. We administered both the Mini International Neuropsychiatric Inventory and the Korean version of the Consortium to Establish a Registry for Alzheimer’s Disease Assessment Packet clinical and neuropsychological battery. We diagnosed depressive disorders according to the Diagnostic and Statistical Manual of Mental Disorders, fourth edition diagnostic criteria, and evaluated the severity of depressive symptoms using the revised Korean version of the Geriatric Depression Scale. Subjects were divided into two groups : 1) depressed group, 2) non-depressed group. We compared sensitivity, specificity, positive predictive value, negative predictive value, receiver operating characteristic curve, and areas of under the curve (AUC) of MMSE between two groups.

Results:AUC of total group was 0.803 [95% confidence interval (CI)=0.774-0.833]. AUC of non-depressed group was the higher (0.855 ; 95% CI=0.823-0.887) than that of depressed group (0.767 ; 95% CI=0.710-0.824, p<0.009).

Conclusion:In non-depressed group, diagnostic accuracy and positive predictive value were higher than those of depressed group. Depression should be considered for effective and efficient national dementia screening and registry program.

키워드

Depression, Screening, Dementia, Mini-Mental State Examination, Positive predictive value
원문 및 링크아웃 정보
등재저널 정보
학술진흥재단(KCI) KoreaMed 대한의학회 회원 
주제코드
주제명(Target field)
연구대상(Population)
연구참여(Sample size)
대상성별(Gender)
질병특성(Condition Category)
연구환경(Setting)
연구설계(Study Design)
연구기간(Period)
중재방법(Intervention Type)
중재명칭(Intervention Name)
키워드(Keyword)
유효성결과(Recomendation)
In non-depressed group, diagnostic accuracy and positive predictive value were higher than those of depressed group.
연구비지원(Fund Source)
근거수준평가(Evidence Hierarchy)
출판년도(Year)
참여저자수(Authors)
대표저자
DOI
KCD코드
ICD 03
건강보험코드