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Influence of Depression on the Prediction Accuracy of Mini-Mental State Examination as Screening Test for Early Detection of Dementia
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±è¼¼¹ü(Kim Se-Beom) - ´Ü±¹´ëÇб³ ÀÇ°ú´ëÇÐ Á¤½Å°úÇб³½Ç
ÀÌÁ¤Àç(Lee Jung-Jae) - ´Ü±¹´ëÇб³ ÀÇ°ú´ëÇÐ Á¤½Å°úÇб³½Ç
À̼®¹ü(Lee Seok-Bum) - ´Ü±¹´ëÇб³ ÀÇ°ú´ëÇÐ Á¤½Å°úÇб³½Ç
ÀÌ°æ±Ô(Lee Kyung-Kyu) - ´Ü±¹´ëÇб³ ÀÇ°ú´ëÇÐ Á¤½Å°úÇб³½Ç
¹é±âû(Paik Ki-Chung) - ´Ü±¹´ëÇб³ ÀÇ°ú´ëÇÐ Á¤½Å°úÇб³½Ç
Abstract
Objective£ºDepression and cognitive impairment are closely associated in old age. In this study, we investigate the influence of depression on the prediction accuracy of Mini-Mental State Examination (MMSE) as screening test for early detection of dementia.
Methods£ºThree hundred and twenty one dementia patients and five hundred and thirty five normal control subjects were enrolled in this study. We administered both the Mini International Neuropsychiatric Inventory and the Korean version of the Consortium to Establish a Registry for Alzheimer¡¯s Disease Assessment Packet clinical and neuropsychological battery. We diagnosed depressive disorders according to the Diagnostic and Statistical Manual of Mental Disorders, fourth edition diagnostic criteria, and evaluated the severity of depressive symptoms using the revised Korean version of the Geriatric Depression Scale. Subjects were divided into two groups : 1) depressed group, 2) non-depressed group. We compared sensitivity, specificity, positive predictive value, negative predictive value, receiver operating characteristic curve, and areas of under the curve (AUC) of MMSE between two groups.
Results£ºAUC of total group was 0.803 [95% confidence interval (CI)=0.774-0.833]. AUC of non-depressed group was the higher (0.855 ; 95% CI=0.823-0.887) than that of depressed group (0.767 ; 95% CI=0.710-0.824, p£¼0.009).
Conclusion£ºIn non-depressed group, diagnostic accuracy and positive predictive value were higher than those of depressed group. Depression should be considered for effective and efficient national dementia screening and registry program.
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Depression, Screening, Dementia, Mini-Mental State Examination, Positive predictive value
KMID :
0869220160200020108
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À¯È¿¼º°á°ú(Recomendation)
In non-depressed group, diagnostic accuracy and positive predictive value were higher than those of depressed group.